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Randomized crossover clinical studies to assess abuse liability and nicotine pharmacokinetics of Velo Oral Nicotine pouches

Frontiers in Pharmacology, 2025

Authors: M. N. Kanobe; C. Y. Powell; P. Makena; S. A. Baxter; M. A. Tapia; J. Darnell; K. Prevette; A. G. Gibson; S. A. Ayoku; L. Campbell; J. W. Coffield; B. M. Keyser; B. S. Ganesh; N. Gale; K. G. Jordan
Product Type: Oral Nicotine Products
Study Type: Clinical Studies

A framework for the systematic evaluation of a novel cigarette filter technology

Food and Chemical Toxicology, 2024

Authors: I. Crooks; D. Thorne; M. West; K. Prasad; A. Gray; C. West; P. Wan; R. Savory, I. Suarez, C. Garcia-Canton
Product Type: Cigarettes
Study Type: Chemistry, Toxicology, Consumer Use Behaviour

An exploratory, randomised, crossover study to investigate the effect of nicotine on cognitive function in healthy adult smokers who use an electronic cigarette after a period of smoking abstinence

Harm Reduction Journal, 2024

Authors: H. J. Green; O. K. O'Shea; J. Cotter; H. L. Philpott; N. Newland
Product Type: Vapour Products
Study Type: Clinical Studies

An in vitro toxicological assessment of two electronic cigarettes: E-liquid to aerosolisation

Current Research in Toxicology, 2024

Authors: E. Bishop; F. Miazzi; S. Bozhilova; N. East; R. Evans; D. Smart; M. Gaca; D. Breheny; D. Thorne
Product Type: Vapour Products
Study Type: Toxicology

Applying new approach methodologies to assess next-generation tobacco and nicotine products

Frontiers in Toxicology, 2024

Authors: D. Thorne; D. McHugh; L. Simms; K. M. Lee; H. Fujimoto; S. Moses; M. Gaca
Product Type: Oral Tobacco Products, Oral Nicotine Products, Vapour Products, Heated Products
Study Type: Toxicology

Assessing Product Use Behavior and Exposure: Definitions and Methods

Contributions to Tobacco & Nicotine Research, 2024

Authors: D. Yuki; L. Giles; M. Scherer; N. Pluym; T. Ljung; E. Mason; K. Newland; C. Chrea; D. T. Djoko; P. Makena; X. Cahours; K. Prasad
Product Type: Oral Tobacco Products, Oral Nicotine Products, Vapour Products, Heated Products
Study Type: Consumer Use Behaviour, Clinical Studies

Assessment of abuse liability and nicotine pharmacokinetics of glo Heated Tobacco Products in a randomized, crossover study

European Journal of Drug Metabolism and Pharmacokinetics, 2024

Authors: M. N. Kanobe; P. Makena; K. Prevette; S. A. Baxter
Product Type: Heated Products
Study Type: Clinical Studies

Comparative toxicological assessment of cigarettes and new category products via an in vitro multiplex proteomics platform

Toxicology Reports, 2024

Authors: N. Tsolakos ; L. E. Haswell; F. Miazzi; E. Bishop; A. Antoranz; V. Pliaka; A. Minia; L. G. Alexopoulos; M. Gaca; D. Breheny
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

Evaluation of cytotoxicity and oxidative stress of whole aerosol from vuse alto ENDS products

Toxics, 2024

Authors: B. M. Keyser; R. Leverette; J. Wertman; T. Shutsky; R. McRae; K. Szeliga; P. Makena; K. Jordan
Product Type: Vapour Products
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Evaluation of environmental emissions from glo heated tobacco products and combustible Cigarettes

Environmental Advances, 2024

Authors: M. N. Kanobe; G. M. Dull; J. Darnell; T. Jin; B. Brown; J. Coffield; B. M. Keyser; I. M. Fearon; P. Makena; S. A. Baxter; K G. Jordan
Product Type: Heated Products
Study Type: Chemistry, Consumer Impact Science

In vitro toxicological evaluation of glo menthol and non-menthol heated tobacco products

Toxicology, 2024

Authors: B. M. Keyser; R. Leverette; R. McRae; J. Wertman; T. Shutsky; K. Jordan; K. Szeliga; P. Makena
Product Type: Heated Products
Study Type: Toxicology

In vitro toxicological evaluation of pouched portioned oral nicotine products

Frontiers in Toxicology, 2024

Authors: B. M. Keyser; R. Leverette; R. McRae; J. Wertman; T. Shutsky; K. Szeliga; P. Makena; K. Jordan
Product Type: Oral Nicotine Products, Oral Tobacco Products
Study Type: Toxicology

In vitro permeation of nicotine and tobacco specific nitrosamines from smokeless tobacco product extracts in a 3D buccal tissue model

Toxicology Letters, 2024

Authors: B. M. Keyser; H. Flockton; R. A. Weidman; R. Payne; J. Rowe; K. G. Jordan
Product Type: Oral Tobacco Products
Study Type: Toxicology

Modelling the nicotine pharmacokinetic profile for e-cigarettes using real time monitoring of consumers' physiological measurements and mouth level exposure

BioData Mining, 2024

Authors: K. Prasad; A. Griffiths; K. Agrawal; M. McEwan; F. Macci; M. Ghisoni; M. Stopher; M. Napleton; J. Strickland; D. Keating; T. Whitehead; G. Conduit; S. Murray; L. Edward
Product Type: Vapour Products
Study Type: Clinical Studies

Multi-endpoint in vitro toxicological assessment of snus and tobacco-free nicotine pouch extracts

Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 2024

Authors: F. Yu; E. Bishop; F. Miazzi; R. Evans; D. Smart; D. Breheny; D. Thorne
Product Type: Oral Tobacco Products, Oral Nicotine Products
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Purchase Intent and Intended Use of the glo Heated Tobacco Product

American Journal of Health Behavior, 2024

Authors: G. M. Curtin; K. K. Gerlach; J. L. Pillitteri; D. R. Battista; R. Chae; M. Polster
Product Type: Heated Products
Study Type: Consumer Use Behaviour

A contextualised e-cigarette testing strategy shows flavourings do not impact lung toxicity in vitro

Toxicology Letters, 2023

Authors: E. Bishop; N. East; F. Miazzi; S. Fiebelkorn; D. Breheny; M. Gaca; D. Thorne
Product Type: Vapour Products
Study Type: Toxicology

A liquid chromatography-tandem mass spectrometry method for the analysis of sucralose and five glycoside sweeteners

Separation Science Plus, 2023

Authors: S. C. Moldoveanu
Study Type: Chemistry

A Systematic Review of Preclinical Studies Evaluating the Association between Nicotine and the Initiation and Progression of Cancer

Annals of Translational Medicine, 2023

Authors: M. M. Kim; I. Steffensen; R. T. D. Miguel; T. Babic; A. D. Johnson; R. Potts; C. S. Junker
Product Type: Nicotine
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Abuse liability of two electronic nicotine delivery systems compared with combustible cigarettes and nicotine gum from an open-label randomized crossover study

Randomized Controlled Trial, 2023

Authors: C. Campbell; T. Jin; E. K. Round; P. R. Nelson; S. Baxter
Product Type: Vapour Products, Cigarettes
Study Type: Clinical Studies

Advances in whole aerosol approaches for in vitro e-cigarette testing

Drug Testing and Analysis, 2023

Authors: E. Bishop; M. Gaca; D. Thorne
Product Type: Vapour Products
Study Type: Toxicology

Assessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics

Scientific Reports, 2023

Authors: J. Frosina; M. McEwan; J. Ebajemito; J. Thissen; K. Taluskie; S. Baxter-Wright; G. Hardie
Product Type: Vapour Products
Study Type: Clinical Studies

Assessment of biomarkers of exposure and potential harm, and physiological and subjective health measures in exclusive users of nicotine pouches and current, former and never smokers

Biomarkers, 2023

Authors: D. Azzopardi; L. E. Haswell; J. Frosina; M. McEwan; N. Gale; J. Thissen; F. Meichanetzidis; G. Hardie
Product Type: Oral Nicotine Products
Study Type: Clinical Studies

Biomarkers of exposure and potential harm in exclusive users of electronic cigarettes and current, former, and never smokers

Internal and Emergency Medicine, 2023

Authors: L. E. Haswell; N. Gale; E. Brown; D. Azzopardi; M. McEwan; J. Thissen; F. Meichanetzidis; G. Hardie
Product Type: Vapour Products, Cigarettes
Study Type: Clinical Studies

Biomarkers of Exposure and Potential Harm in Two Weeks of Smoking Abstinence: Changes in Biomarkers of Platelet Function, Oxidative Stress, and Inflammation

International Journal of Molecular Sciences, 2023

Authors: P. Makena; E. Scott; P. Chen; H. P. Liu; B. A. Jones; G. L. Prasad
Product Type: Cigarettes
Study Type: Clinical Studies, Preclinical/In Vitro Disease Assessment

Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems

Toxics, 2023

Authors: M. N. Kanobe; P. R. Nelson; B. G. Brown; P. T. Chen; P. Makena; J. W. Caraway; G. L. Prasad; E. K. Round
Product Type: Vapour Products
Study Type: Clinical Studies

Comparative study of the effects of cigarette smoke versus next-generation tobacco and nicotine product extracts on inflammatory biomarkers of human monocytes

Pflugers Archiv-European Journal of Physiology, 2023

Authors: S. Giebe; M. Brux; A. Hofmann; F. Lowe; D. Breheny; H. Morawietz; C. Brunssen
Product Type: Nicotine, Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Comparison of several HPLC methods for the analysis of vitamin C

Biomedical Chromatography, 2023

Authors: S. C. Moldoveanu
Study Type: Chemistry

Comparison of two methods for ginsenosides quantitation

Journal of Separation Science, 2023

Authors: S. C. Moldoveanu; H. M. Gan
Study Type: Chemistry

Heaviness of smoking index in menthol and non-menthol smokers

Journal of Addictive Diseases, 2023

Authors: K. Frost-Pineda; M. Polster
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Identification and quantitation of nicotine polacrilex in nicotine pouches and other oral nicotine delivery products

Contributions to Tobacco & Nicotine Research, 2023

Authors: S. C. Moldoveanu
Product Type: Oral Nicotine Products, Nicotine
Study Type: Chemistry

Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters

Atla-Alternatives to Laboratory Animals, 2023

Authors: M. M. Moore; I. Abraham; M. Ballantyne; H. Behrsing; X. F. Cao; J. Clements; M. Gaca; G. Gillman; T. Hashizume; R. H. Heflich; S. Hurtado; K. G. Jordan; R. Leverette; D. McHugh; J. Miller-Holt; G. Phillips; L. Recio; S. Roy; M. Scian; L. Simms; D. J. Smart; L. F. Stankowski; R. Tarran; D. Thorne; E. Weber; R. Wieczorek; K. Yoshino; R. Curren
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology

Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for the in vitro mouse lymphoma assay

Alternatives to Laboratory Animals, 2023

Authors: I. Crooks; J. Clements; R. Curren; X. Guo; M. Hollings; M. Lloyd; D. Smart; D. Thorne; E. Weber; M. Moore
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology

Oxidative Stress and Lung Fibrosis: Towards an Adverse Outcome Pathway

International Journal of Molecular Sciences, 2023

Authors: P. Makena; T. Kikalova; G. L. PrasadL; S. A. Baxter
Product Type: Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

Part two: an unblinded, parallel, randomized study to assess nicotine pharmacokinetics of four Vuse Solo ENDS flavors in smokers

Scientific Reports, 2023

Authors: B. M. Keyser; K. S. Hong; P. DeLuca; T. Jin; B. A. Jones; P. Nelson; E. Schmidt; E. K. Round
Product Type: Vapour Products
Study Type: Clinical Studies

Partial Vapor Pressures, Activity Coefficients, Henry Volatility, and Infinite Dilution Activity Coefficients of Nicotine from Binary Mixtures with Glycerol and with 1,2-Propanediol at 298.15 K

ACS Omega, 2023

Authors: F. K. S. Charles; S. C. Moldoveanu
Product Type: Vapour Products, Nicotine
Study Type: Chemistry

Plasma Nicotine Pharmacokinetics of Oral Nicotine Pouches Across Varying Flavours and Nicotine Content

Contributions to Tobacco & Nicotine Research, 2023

Authors: M. McEwan; L. E. Haswell; S. Baxter-Wright; F. Meichanetzidis; T. Jin; G. Hardie
Product Type: Oral Nicotine Products
Study Type: Clinical Studies

Purchase Intent and Appeal of ENDS Products among Current, Former and Never Ever Users of Tobacco Products in the U.S.

Contributions to Tobacco & Nicotine Research, 2023

Authors: K. Frost-Pineda; R. Chae; N. Dianno; R. E. Freeland; M. Polster
Product Type: Vapour Products
Study Type: Population Health Impact

Purchase Intent and Product Appeal of Velo Nicotine Pouches Among Current Tobacco Users and Nonusers of Tobacco

Contributions to Tobacco & Nicotine Research, 2023

Authors: R. E. Freeland; D. R. Battista; M. Polster; R. Cha; N. Dianno; K. Frost-Pineda
Product Type: Oral Nicotine Products
Study Type: Population Health Impact

Rapid determination of levels of the main constituents in e-liquids by near infrared spectroscopy

Scientific Reports, 2023

Authors: A. R. F. Hoffmann; J. Jeffery; P. Dallin; J. Andrews; M. Brokl
Product Type: Vapour Products
Study Type: Chemistry

Revisiting the dependence of retention factor on the content of organic component in the mobile phase in reversed-phase HPLC

Journal of Separation Science, 2023

Authors: S. C. Moldoveanu; E. Bacalum; T. Galaon; V. David
Study Type: Chemistry

Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use

Frontiers in Cardiovascular Medicine, 2023

Authors: M. M. Kim; I. Steffensen; R. T. D. Miguel; T. Babic; A. D. Johnson; J. Carlone; R. Potts; C. S. Junker
Product Type: Nicotine, Oral Nicotine Products
Study Type: Clinical Studies, Preclinical/In Vitro Disease Assessment

Two Techniques for the Analysis of WS-3 With Potential Application to the Analysis of Other Cooling Agents

Contributions to Tobacco & Nicotine Research, 2023

Authors: S. C. Moldoveanu; R. O. Bussey
Product Type: Oral Nicotine Products, Cigarettes
Study Type: Chemistry

Using a Novel Connected Device for the Collection of Puffing Topography Data for the Vuse Solo Electronic Nicotine Delivery System in a Real-World Setting: Prospective Ambulatory Clinical Study

JMIR Formative Research, 2023

Authors: R. Underly; G. M. Dull; E. Nudi; T. Pionk; K. Prevette; J. Smith
Product Type: Vapour Products
Study Type: Consumer Use Behaviour

Validation of the VITROCELL® Mammalian 48 exposure module using in vitro cytotoxicity in CHO cells using the Neutral Red Uptake Assay following exposure to whole smoke from combustible cigarettes

Applied In Vitro Toxicology, 2023

Authors: B. M. Keyser; R. Leverette; M. Hollings; E. Rothwell; R. A. Weidman; C. J. Bequette; K. Jordan
Product Type: Cigarettes
Study Type: Toxicology

A 3D in vitro comparison of two undiluted e-cigarette aerosol generating systems

Toxicology Letters, 2022

Authors: E. Bishop; A. Terry; N. East; D. Breheny; M. Gaca; D. Thorne
Product Type: Vapour Products
Study Type: Toxicology

A comparison of cigarette smoke test matrices and their responsiveness in the mouse lymphoma assay: A case study

Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2022

Authors: I. Crooks; M. Hollings; R. Leverette; K. Jordan; D. Breheny; M. M. Moore; D. Thorne
Product Type: Cigarettes
Study Type: Toxicology

A novel clinical method to measure skin staining reveals activation of skin damage pathways by cigarette smoke

Skin Research and Technology, 2022

Authors: A. Dalrymple; M. McEwan; M. Brandt; S. Bielfeldt; E. J. Bean; A. Moga; S. Coburn; G. Hardie
Product Type: Cigarettes
Study Type: Consumer Impact Science

A randomised study to assess the nicotine pharmacokinetics of an oral nicotine pouch and two nicotine replacement therapy products

Scientific Reports, 2022

Authors: D. Azzopardi; J. Ebajemito; M. McEwan; O. M. Camacho; J. Thissen; G. Hardie; R. Voisine; G. Mullard; Z. Cohen; J. Murphy
Product Type: Oral Nicotine Products
Study Type: Clinical Studies

A Randomised Study to Investigate the Nicotine Pharmacokinetics of Oral Nicotine Pouches and a Combustible Cigarette

European Journal of Drug Metabolism and Pharmacokinetics, 2022

Authors: M. McEwan; D. Azzopardi; N. Gale; O. M. Camacho; G. Hardie; I. M. Fearon; J. Murphy
Product Type: Oral Nicotine Products, Cigarettes
Study Type: Clinical Studies

A Systematic Review and Meta-analysis of the Association between E-cigarette Use among Cigarette Smokers and Quit Attempts Made to Abstain from Cigarette Smoking

American Journal of Health Behavior, 2022

Authors: M. M. Kim; I. Steffensen; R. D. Miguel; J. Carlone; G. M. Curtin
Product Type: Vapour Products
Study Type: Consumer Use Behaviour

Actual use puffing topography and mouth level exposure to aerosol and nicotine for an evolving series of electronic nicotine delivery system

International Journal of Scientific Reports, 2022

Authors: K. Prasad; A. Gray; L. Edward
Product Type: Vapour Products
Study Type: Consumer Use Behaviour

An abuse liability assessment of the glo tobacco heating product in comparison to combustible cigarettes and nicotine replacement therapy

Scientific Reports, 2022

Authors: G. Hardie; N. Gale; M. McEwan; S. M. Oscar; L. Ziviani; C. J. Proctor; J. Murphy
Product Type: Heated Products
Study Type: Clinical Studies

An experimental analytical and in vitro approach to bridging between different heated tobacco product variants

Contributions to Tobacco & Nicotine Research, 2022

Authors: T. Jaunky; D. Thorne; A. Baxter; S. Hadley; J. Frosina; D. Breheny; J. Murphy; M. Gaca
Product Type: Heated Products
Study Type: Chemistry, Toxicology

An exploratory, randomised, crossover study to investigate the effect of nicotine on cognitive function in healthy adult smokers who use an electronic cigarette, after a period of smoking abstinence: study protocol

International Journal of Clinical Trials, 2022

Authors: H. J. Green; O. K. O'Shea; H. L. Philpott; N. Newland
Product Type: Vapour Products
Study Type: Clinical Studies

Application of ToxTracker for the toxicological assessment of tobacco and nicotine delivery products

Toxicology Letters, 2022

Authors: D. E. Smart; S. Bozhilova; F. Miazzi; L. E. Haswell; M. D. Gaca; D. Thorne; D. Breheny
Product Type: Vapour Products, Heated Products
Study Type: Toxicology

Assessing consumer use and behaviour patterns of oral nicotine pouches in a multi-country study

International Journal of Scientific Reports, 2022

Authors: K. Prasad; M. Shetty; C. Kanitscheider; B. Szentes; R. Nassar; L. Edward
Product Type: Oral Nicotine Products
Study Type: Consumer Use Behaviour

Assessing the Evidence on the Differential Impact of Menthol versus Non-menthol Cigarette Use on Initiation and Progression to Regular Smoking: A Systematic Review and Meta-analysis

American Journal of Health Behavior, 2022

Authors: M. M. Kim; G. M. Curtin
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Assessing the Evidence on the Differential Impact of Menthol versus Non-menthol Cigarette Use on Smoking Dependence in the US Population: A Systematic Review and Meta-analysis

American Journal of Health Behavior, 2022

Authors: M. M. Kim; G. M. Curtin
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Biomarkers of Exposure and Potential Harm in Exclusive Users of Electronic Cigarettes and Current, Former and Never-Smokers: A Cross-Sectional Study Protocol

Journal of Health and Environmental Research, 2022

Authors: N. Gale; L. E. Haswell; M. McEwan; D. Azzopardi; J. Thissen; G. Hardie
Product Type: Vapour Products, Cigarettes
Study Type: Clinical Studies

Biomarkers of Exposure and Potential Harm in Exclusive Users of Nicotine Pouches and Current, Former, and Never Smokers: Protocol for a Cross-sectional Clinical Study

JMIR Research Protocols, 2022

Authors: D. Azzopardi; L. E. Haswell; J. Frosina; M. McEwan; N. Gale; J. Thissen; F. Meichanetzidis; G. Hardie
Product Type: Oral Nicotine Products
Study Type: Clinical Studies

Bridging: Accelerating Regulatory Acceptance of Reduced-Risk Tobacco and Nicotine Products

Nicotine & Tobacco Research, 2022

Authors: M. Gaca; J. Williamson; H. Digard; L. Adams; L. Hawkridge; C. Proctor
Product Type: Oral Nicotine Products, Vapour Products, Heated Products
Study Type: Chemistry

Changes in biomarkers of exposure and biomarkers of potential harm after 360 days in smokers who either continue to smoke, switch to a tobacco heating product or quit smoking

Internal and Emergency Medicine, 2022

Authors: N. Gale; M. McEwan; G. Hardie; C. J. Proctor; J. Murphy
Product Type: Heated Products
Study Type: Clinical Studies

Characterization of Aerosol Deliveries from Combustible Cigarettes, Heated Tobacco Products, and Electronic Nicotine Delivery Systems Using the Vitrocell Ames 48

Applied In Vitro Toxicology, 2022

Authors: B. M. Keyser; R. Leverette; M. Hollings; A. Seymour; R. A. Weidman; C. J. Bequette; K. Jordan
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology

Characterization of smoke and aerosol deliveries from combustible cigarettes, heated tobacco products and electronic nicotine delivery systems in the Vitrocell® Mammalian 6/48 exposure module

Toxicology Reports, 2022

Authors: B. M. Keyser, R. Leverette, M.l Hollings, A. Seymour, R. A. Weidman, C. J. Bequette, K. Jordan
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology

Chemical characterisation of the Vapour Products emitted by an e-cigarette using a ceramic wick-based technology

Scientific Reports, 2022

Authors: M. I. Pinto; J. Thissen; N. Hermes; A. Cunningham; H. Digard; J. Murphy
Product Type: Vapour Products
Study Type: Chemistry

Chemical characterization of tobacco-free "modern" oral nicotine pouches and their position on the toxicant and risk continuums

Drug and Chemical Toxicology, 2022

Authors: D. Azzopardi; C. Liu; J. Murphy
Product Type: Oral Nicotine Products
Study Type: Chemistry

Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance

Atla-Alternatives to Laboratory Animals, 2022

Authors: H. P. Behrsing; A. Wahab; L. Ukishima; C. Grodi; S. Frentzel; S. Johne; S. Ishikawa; S. Ito; R. Wieczorek; J. Budde; B. M. Keyser; L. E. Haswell; D. Thorne; E. Bishop; D. Breheny; X. F. Cao; Q. Qin; V. Patel
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Commentary: Cigarette dependence in menthol and non-menthol young adult cigarette smokers

Journal of Addictive Diseases, 2022

Authors: K. Frost-Pineda; M. Polster
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Cytotoxicity, oxidative stress, and inflammatory response of smokeless tobacco extracts and cytotoxicity of combustible cigarette whole smoke in a 3D oral organotypic buccal cell model

Toxicology mechanisms and methods, 2022

Authors: B. M. Keyser
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Designing Studies to Inform Tobacco Harm Reduction: Learnings From an Oral Nicotine Pouch Actual Use Pilot Study

JMIR Formative Research, 2022

Authors: C. Campbell; M. Feehan; C. Kanitscheider; P. S. Makena; J. Cai; S. A. Baxter
Product Type: Oral Nicotine Products
Study Type: Consumer Use Behaviour

Differential gene expression of 3D primary human airway cultures exposed to cigarette smoke and electronic nicotine delivery system (ENDS) preparations

BMC Medical Genomics, 2022

Authors: R. E. Rayner; P. Makena; G. Liu; G. L. Prasad; E. Cormet-Boyaka
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology

Does the level of NNK in tobacco and tobacco products depend on the level of pseudooxynicotine or of nicotine-1-N-oxide?

Contributions to Tobacco & Nicotine Research, 2022

Authors: J. Huihua; S. C. Moldoveanu
Product Type: Tobacco
Study Type: Chemistry

Emissions, puffing topography, mouth level exposure and consumption among Japanese users of tobacco heated products

International Journal of Scientific Reports, 2022

Authors: K. Prasad; A. Gray; L. Edward; C. Goss
Product Type: Heated Products
Study Type: Chemistry, Consumer Use Behaviour

Evaluation of behavioural, chemical, toxicological and clinical studies on a tobacco heated product gloTM and the potential for bridging from a foundational dataset to new iterations

Toxicology Reports, 2022

Authors: S. Goodall; N. Gale; D. Thorne; S. Hadley; K. Prasad; I. Gilmour; F. Miazzi; C. Proctor
Product Type: Heated Products
Study Type: Chemistry

Grafting of amine functions on cellulose acetate fibers by branched polyethylenimine coating

Reactive & Functional Polymers, 2022

Authors: K. Bourahla; Y. Lemmouchi; C. Jama; C. Rolando; A. Mazzah
Product Type: Cigarettes

Human Abuse Liability Assessment of Tobacco and Nicotine Products: Approaches for Meeting Current Regulatory Recommendations

Nicotine & Tobacco Research, 2022

Authors: A. Vansickel; S. Baxter; N. Sherwood; M. Kong; L. Campbell
Product Type: Oral Nicotine Products, Oral Tobacco Products, Vapour Products, Heated Products
Study Type: Clinical Studies

Interconversion of nicotine enantiomers during heating and implications for smoke from combustible cigarettes, heated tobacco products, and electronic cigarettes

Chirality, 2022

Authors: S. C. Moldoveanu
Product Type: Vapour Products, Heated Products, Cigarettes, Nicotine
Study Type: Chemistry

Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry

Drug Testing and Analysis, 2022

Authors: J. Miller-Holt; H. Behrsing; I. Crooks; R. Curren; K. Demir; J. Gafner; G. Gillman; M. Hollings; R. Leverette; M. Oldham; L. Simms; L. F. Stankowski; D. Thorne; R. Wieczorek; M. M. Moore
Product Type: Vapour Products, Heated Products
Study Type: Toxicology

Part one: abuse liability of Vuse Solo (G2) electronic nicotine delivery system relative to combustible cigarettes and nicotine gum

Scientific Reports, 2022

Authors: C. Campbell; T. Jin; E. K. Round; E. Schmidt; P. Nelson; S. Baxter
Product Type: Vapour Products
Study Type: Clinical Studies

Part three: a randomized study to assess biomarker changes in cigarette smokers switched to Vuse Solo or Abstinence

Scientific Reports, 2022

Authors: M. N. Kanobe; B. A. Jones; P. Nelson; B. Brown; P. Chen; P. Makena; E. Schmidt; J. Darnell; J. W. Caraway; G. L. Prasad; B. Nordskog; E. K. Round
Product Type: Vapour Products
Study Type: Clinical Studies

Pilot study to determine differences in breath odour between cigarette and e-cigarette consumers

Scientific Reports, 2022

Authors: A. Dalrymple; S. Coburn; M. Brandt; G. Hardie; J. Murphy
Product Type: Vapour Products, Cigarettes
Study Type: Consumer Impact Science

Population estimates of biomarkers of exposure to carbon monoxide, nicotine and NNK in smokers and nonsmokers.

Qeios, 2022

Authors: F. Ayala-Fierro; T. Verron; P. Lizhnyak; R. Freeland; K. Frost-Pineda; A. Elamin; G. Prasad; M. Sarkar
Product Type: Cigarettes
Study Type: Clinical Studies

Principles and procedures for assessment of acute toxicity incorporating in silico methods

Computational Toxicology, 2022

Authors: C. M. Zwickl; J. C. Graham; R. A. Jolly; A. Bassan; E. Ahlberg; A. Amberg; L. T. Anger; L. Beilke; P. Bellion; A. Brigo; H. Burleigh-Flayer; M. T. D. Cronin; A. A. Devlin; T. Fish; S. Glowienke; K. Gromek; A. L. Karmaus; R. Kemper; S. Kulkarni; E. Lo Piparo; F. Madia; M. Martin; M. Masuda-Herrera; B. L. Mcatee; J. Mestres; L. Milchak; C. Moudgal; M. Mumtaz; W. Muster; L. Neilson; G. Patlewicz; A. Paulino; A. Roncaglioni; P. Ruiz; D. T. Szabo; J. P. Valentin; I. Vardakou; D. Woolley; G. J. Myatt
Study Type: Toxicology

Puffing topography and Mouth Level Exposure of two closed-system Vype e-cigarettes

International Journal of Scientific Reports, 2022

Authors: K. Prasad; A. Gray; L. Edward
Product Type: Vapour Products
Study Type: Consumer Use Behaviour

Rapid quantification of alkaloids, sugar and yield of tobacco (Nicotiana tabacum L.) varieties by using Vis-NIR-SWIR spectroradiometry

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2022

Authors: M. Rodrigues; R. B. de Oliveira; G. L. A. A. dos Santos; K. M. de Oliveira; A. S. Reis; R. H. Furlanetto; L. A. Y. Bernardo; F. S. Coelho; M. R. Nanni
Product Type: Tobacco
Study Type: Chemistry, Agronomy

Strategies for the recurrent selection program in tobacco breeding for green leaf yield

Crop Science, 2022

Authors: T. L. Marques; J. M. V. Padua; I. J. Berger; M. A. P. Ramalho
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Transcriptomic Response of Primary Human Bronchial Cells to Repeated Exposures of Cigarette and ENDS Preparations

Cell Biochemistry and Biophysics, 2022

Authors: R. E. Rayner; J. Wellmerling; P. Makena; J. Zhao; G. L. Prasad; E. Cormet-Boyaka
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology

A Laboratory Method to Measure Skin Surface Staining by Cigarette Smoke, Tobacco Heating Products and E-Cigarettes

Contributions to Tobacco & Nicotine Research, 2021

Authors: A. Dalrymple; E.-J. Bean; J. Thissen; H. Behrsing; S. Coburn; J. Murphy
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Consumer Impact Science

A randomized controlled study in healthy participants to explore the exposure continuum when smokers switch to a tobacco heating product or an E-cigarette relative to cessation

Toxicology Reports, 2021

Authors: M. McEwan; N. Gale; J. K. Ebajemito; O. M. Camacho; G. Hardie; C. J. Proctor; J. Murphy
Product Type: Vapour Products, Heated Products
Study Type: Clinical Studies

A screening approach for the evaluation of tobacco-free 'modern oral' nicotine products using Real Time Cell Analysis

Toxicology Reports, 2021

Authors: N. East; E. Bishop; D. Breheny; M. Gaca; D. Thorne
Product Type: Oral Nicotine Products
Study Type: Toxicology

A Single-Center Evaluation of Environmental Emissions from ENDS and Combustible Cigarettes

Contributions to Tobacco & Nicotine Research, 2021

Authors: J. W. Caraway; T. Jin; E. Schmidt; P. R. Nelson
Product Type: Vapour Products, Cigarettes
Study Type: Chemistry, Consumer Impact Science

A survey of aerosol exposure systems relative to the analysis of cytotoxicity: A Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) perspective

Toxicology Research and Application, 2021

Authors: D. Thorne; R. Wieczorek; T. Fukushima; H.-J. Shin; R. Leverette; M. Ballantyne; X. Li; B. Bombick; K. Yoshino
Study Type: Toxicology

An adverse outcome pathway for decreased lung function focusing on mechanisms of impaired mucociliary clearance following inhalation exposure

Frontiers in Toxicology, 2021

Authors: K. Luettich; M. Sharma; H. Yepiskoposyan; D. Breheny; F. J. Lowe
Study Type: Preclinical / In Vitro Disease Assessment

An interlaboratory in vitro aerosol exposure system reference study

Toxicology Research and Application, 2021

Authors: D. Thorne; J. Adamson; E. T. Sticken; R. Wieczorek; H. Behrsing; S. Steiner; S. Majeed; S. Frentzel; S. Ishikawa; S. Ito; L. Simms; K. Yoshino; J. Hoeng; M. Gaca
Product Type: Cigarettes
Study Type: Toxicology

Antioxidant Character and Levels of Polyphenols in Several Tea Samples

ACS Omega, 2021

Authors: S. C. Moldoveanu; R. Oden
Study Type: Chemistry

Application of text mining to develop AOP-based mucus hypersecretion genesets and confirmation with in vitro and clinical samples

Scientific Reports, 2021

Authors: E. Minet; L. E. Haswell; S. Corke; A. Banerjee; A. Baxter; I. Verrastro; F. D. E. Lima; T. Jaunky; S. Santopietro; D. Breheny; M. D. Gaca
Product Type: Vapour Products, Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

Assessing the evidence on the differential impact of menthol versus non-menthol cigarette use on smoking cessation in the US population: a systematic review and meta-analysis

Substance Abuse Treatment Prevention and Policy, 2021

Authors: M. M. Kim; G. M. Curtin
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Changes in biomarkers after 180 days of tobacco heating product use: a randomised trial

Internal and Emergency Medicine, 2021

Authors: N. Gale; M. McEwan; O. M. Camacho; G. Hardie; C. J. Proctor; J. Murphy
Product Type: Heated Products
Study Type: Clinical Studies

Changes in Biomarkers of Exposure on Switching From a Conventional Cigarette to the glo Tobacco Heating Product: A Randomized, Controlled Ambulatory Study

Nicotine & Tobacco Research, 2021

Authors: N. Gale; M. McEwan; O. M. Camacho; G. Hardie; J. Murphy; C. J. Proctor
Product Type: Heated Products
Study Type: Clinical Studies

Cigarette smoke preparations, not electronic nicotine delivery system preparations, induce features of lung disease in a 3D lung repeat-dose model

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021

Authors: R. E. Rayner; P. Makena; G. L. Prasad; E. Cormet-Boyaka
Product Type: Vapour Products, Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

Comparative study of the effects of cigarette smoke versus next generation tobacco and nicotine product extracts on endothelial function

Redox Biology, 2021

Authors: S. Giebe; A. Hofmann; M. Brux; F. Lowe; D. Breheny; H. Morawietz; C. Brunssen
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

Cross-sectional Survey to Assess Tobacco and Nicotine Product Use since the Introduction of Tobacco Heating Products in Japan: Wave 1

Tobacco Regulatory Science, 2021

Authors: J. D. Jones; J. Adamson; C. Kanitscheider; K. Prasad; O. M. Camacho; E. Beliaeva; H. Bauer; Y. Keralapura; J. Murphy
Product Type: Heated Products
Study Type: Consumer Use Behaviour

Derivatization procedures and their analytical performances for HPLC determination in bioanalysis

Biomedical Chromatography, 2021

Authors: V. David; S. C. Moldoveanu; T. Galaon
Study Type: Chemistry

Diacetyl and Other Ketones in e-Cigarette Aerosols: Some Important Sources and Contributing Factors

Frontiers in Chemistry, 2021

Authors: K. McAdam; G. Waters; S. C. Moldoveanu; J. Margham; A. Cunningham; C. Vas; A. Porter; H. Digard
Product Type: Vapour Products
Study Type: Chemistry

Differences in biomarkers of inflammation and immune responses in chronic smokers and moist snuff users

Cytokine, 2021

Authors: Q. T. Tran; S. Arimilli; E. Scott; P. Chen; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Clinical Studies

Enamel staining with e-cigarettes, tobacco heating products and modern oral nicotine products compared with cigarettes and snus: An in vitro study

American Journal of Dentistry, 2021

Authors: A. Dalrymple; E. J. Bean; T. C. Badrock; R. A. Weidman; J. Thissen; S. Coburn; J. Murphy
Product Type: Oral Nicotine Products
Study Type: Consumer Impact Science

Estimating the Population Health Impact of Recently Introduced Modified Risk Tobacco Products: A Comparison of Different Approaches

Nicotine & Tobacco Research, 2021

Authors: P. N. Lee; D. Abrams; A. Bachand; G. Baker; R. Black; O. Camacho; G. Curtin; S. Djurdjevic; A. Hill; D. Mendez; R. S. Muhammad-Kah; J. L. Murillo; R. Niaura; Y. B. Pithawalla; B. Poland; S. Sulsky; L. Wei; R. Weitkunat
Product Type: Oral Tobacco Products, Vapour Products, Heated Products
Study Type: Population Health Impact

Evaluation of tobacco lines and hybrids carrying Beinhart-1000 alleles at the Phn15.1 locus for agronomic and disease resistance characteristics

Crop Science, 2021

Authors: C. Heim; J. S. Ma; E. Willard; C. Shelton; R. S. Lewis
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Evidence From the Scientific Assessment of Electronic Cigarettes and Their Role in Tobacco Harm Reduction

Contributions to Tobacco & Nicotine Research, 2021

Authors: O. M. Camacho; J. K. Ebajemito; S. Coburn; K. Prasad; S. Costigan; J. J. Murphy
Product Type: Vapour Products

Feasibility of using tobacco hybrids of the Dark tobacco type

Genetics and Molecular Research, 2021

Authors: A. Pscheidt; R. C. Lemos; J. C. Souza; V. B. Oliveira; A. M. Souza; J. M. V. Padua
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Impact of cigarette versus electronic cigarette aerosol conditioned media on aortic endothelial cells in a microfluidic cardiovascular model

Scientific Reports, 2021

Authors: O. Makwana; G. A. Smith; H. E. Flockton; G. P. Watters; F. Lowe; D. Breheny
Product Type: Vapour Products, Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

In Silico Approaches In Carcinogenicity Hazard Assessment: Current Status and Future Needs

Computational Toxicology, 2021

Authors: R. R. Tice; A. Bassan; A. Amberg; L. T. Anger; M. A. Beal; P. Bellion; R. Benigni; J. Birmingham; A. Brigo; F. Bringezu; L. Ceriani; I. Crooks; K. Cross; R. Elespuru; D. M. Faulkner; M. C. Fortin; P. Fowler; M. Frericks; H. H. J. Gerets; G. D. Jahnke; D. R. Jones; N. L. Kruhlak; E. Lo Piparo; J. Lopez-Belmonte; A. Luniwal; A. Luu; F. Madia; S. Manganelli; B. Manickam; J. Mestres; A. L. Mihalchik-Burhans; L. Neilson; A. Pandiri; M. Pavan; C. V. Rider; J. P. Rooney; A. Trejo-Martin; K. H. Watanabe-Sailor; A. T. White; D. Woolley; G. J. Myatt
Study Type: Toxicology

Investigating the Health Effects of 3 Coexisting Tobacco-Related Products Using System Dynamics Population Modeling: An Italian Population Case Study

Frontiers in Public Health, 2021

Authors: O. M. Camacho; A. Hill; S. Fiebelkorn; A. Williams; J. Murphy
Product Type: Vapour Products, Heated Products
Study Type: Population Health Impact

Metabolomic Analysis Identified Reduced Levels of Xenobiotics, Oxidative Stress, and Improved Vitamin Metabolism in Smokers Switched to Vuse Electronic Nicotine Delivery System

Nicotine & Tobacco Research, 2021

Authors: G. Liu; C. J. Lin; C. R. Yates; G. L. Prasad
Product Type: Vapour Products
Study Type: Clinical Studies

Modeled Respiratory Tract Deposition of Smoke Aerosol from Conventional Cigarettes, Electronic Cigarettes and Heat-not-burn Products

Aerosol and Air Quality Research, 2021

Authors: Y. W. Li; H. P. Cui; L. Chen; M. J. Fan; J. L. Cai; J. W. Guo; C. U. Yurteri; X. X. Si; S. F. Liu; F. W. Xie; J. P. Xie
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Aerosol Physics

Modeling the Population Health Impacts of Heated Tobacco Products in Japan

Tobacco Regulatory Science, 2021

Authors: O. M. Camacho; A. Hill; S. Fiebelkorn; J. D. Jones; K. Prasad; C. Proctor; J. Murphy
Product Type: Heated Products
Study Type: Population Health Impact

NIC1 cloning and gene editing generates low-nicotine tobacco plants

Plant Biotechnology Journal, 2021

Authors: Q. L. Qin; M. Humphry; T. Gilles; A. Fisher; B. Patra; S. K. Singh; D. D. Li; S. M. Yang
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Reporting and methodological quality of systematic literature reviews evaluating the associations between e-cigarette use and cigarette smoking behaviors: a systematic quality review

Harm Reduction Journal, 2021

Authors: M. M. Kim, L. Pound; I. Steffensen; G. M. Curtin
Product Type: Vapour Products, Cigarettes
Study Type: Consumer Use Behaviour

The Chemical Complexity of e-Cigarette Aerosols Compared With the Smoke From a Tobacco Burning Cigarette

Frontiers in Chemistry, 2021

Authors: J. Margham; K. McAdam; A. Cunningham; A. Porter; S. Fiebelkorn; D. Mariner; H. Digard; C. Proctor
Product Type: Vapour Products
Study Type: Chemistry

The development of an in vitro 3D model of goblet cell hyperplasia using MUC5AC expression and repeated whole aerosol exposures

Toxicology Letters, 2021

Authors: L. E. Haswell; D. Smart; T. Jaunky; A. Baxter; S. Santopietro; S. Meredith; O. M. Camacho; D. Breheny; D. Thorne; M. D. Gaca
Product Type: Heated Products
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Variation with Temperature of Phase Ratio in Reversed Phase HPLC for a Methanol/Water Mobile Phase

Chromatographia, 2021

Authors: A. C. Soare; V. David; S. C. Moldoveanu
Study Type: Chemistry

A Combined Study of Headspace Volatiles using Human Sensory, Mass Spectrometry and Chemometrics

Scientific Reports, 2020

Authors: K. G. McAdam; J. Tetteh; L. Bishop; H. Digard; J. Cote; S. Lubbe; C. Liu
Product Type: Oral Tobacco Products
Study Type: Consumer Impact Science

A cross-category puffing topography, mouth level exposure and consumption study among Italian users of tobacco and nicotine products

Scientific Reports, 2020

Authors: J. Jones; S. Slayford; A. Gray; K. Brick; K. Prasad; C. Proctor
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Consumer Use Behaviour

A randomised controlled single-centre open-label pharmacokinetic study to examine various approaches of nicotine delivery using electronic cigarettes

Scientific Reports, 2020

Authors: J. K. Ebajemito; M. McEwan; N. Gale; O. M. Camacho; G. Hardie; C. J. Proctor
Product Type: Vapour Products
Study Type: Clinical Studies

An approach for the extract generation and toxicological assessment of tobacco-free 'modern' oral nicotine pouches

Food and Chemical Toxicology, 2020

Authors: E. Bishop; N. East; S. Bozhilova; S. Santopietro; D. Smart; M. Taylor; S. Meredith; A. Baxter; D. Breheny; D. Thorne; M. Gaca
Product Type: Oral Nicotine Products
Study Type: Toxicology

An experimental aerosol air-agar interface mouse lymphoma assay methodology

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2020

Authors: D. Thorne; M. Hollings; J. Kilford; J. Clements; R. Payne; M. Ballantyne; A. Dalrymple; D. Dillon; C. Meredith; M. Gaca
Product Type: Cigarettes
Study Type: Toxicology

Analysis of ?-Tocopherol in Tobacco and Cigarette Smoke

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2020

Authors: S. C. Moldoveanu
Product Type: Cigarettes, Tobacco
Study Type: Chemistry

Characterization of mainstream cigarette smoke aerosol by size-fractionated chemical analysis of nicotine, solanesol, and tobacco-specific nitrosamines

Particulate Science and Technology, 2020

Authors: H. P. Cui; C. U. Yurteri; R. Cabot; F. W. Xie; H. M. Liu
Product Type: Cigarettes
Study Type: Aerosol Physics, Chemistry

Characterization of Phn15.1, a Newly Identified Phytophthora nicotianae Resistance QTL in Nicotiana tabacum

Plant Disease, 2020

Authors: J. M. Ma; C. B. Heim; M. Humphry; J. M. Nifong; R. S. Lewis
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Chemosensory aerosol assessment of key attributes for tobacco products

Journal of Chemometrics, 2020

Authors: F. L. F. Soares; M. C. A. Marcelo; J. C. Dias; L. C. Juliano; L. M. F. Porte; L. D. S. Canova; J. A. Ardila; O. F. S. Pontes; G. P. Sabin; S. Kaiser
Product Type: Tobacco, Cigarettes
Study Type: Consumer Impact Science

Comprehensive Chemical Characterization of the Aerosol Emissions of a Vaping Product Based on a New Technology

Chemical Research in Toxicology, 2020

Authors: J. Nicol; R. Fraser; L. Walker; C. Liu; J. Murphy; C. J. Proctor
Product Type: Vapour Products
Study Type: Chemistry

Development of a novel method to measure material surface staining by cigarette, e-cigarette or tobacco heating product aerosols

Heliyon, 2020

Authors: A. Dalrymple; T. C. Badrock; A. Terry; E. J. Bean; M. Barber; P. J. Hall; S. Coburn; J. McAughey; J. Murphy
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Consumer Impact Science

Does phase ratio in reversed phase high performance liquid chromatography vary with temperature?

Journal of Chromatography A, 2020

Authors: A. C. Soare; V. David; S. C. Moldoveanu
Study Type: Chemistry

Evaluation of a high-throughput in vitro endothelial cell migration assay for the assessment of nicotine and tobacco delivery products

Toxicology Letters, 2020

Authors: E. Bishop; D. Breheny; K. Hewitt; M. Taylor; T. Jaunky; O. M. Camacho; D. Thorne; M. Gaca
Product Type: Heated Products
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Extraction of Benzo[a]pyrene from Moist Snuff with Water or Artificial Saliva (Part 2)

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2020

Authors: S. C. Moldoveanu; A. Harrison
Product Type: Oral Tobacco Products
Study Type: Chemistry

Gas-Particle Partitioning of Formaldehyde in Mainstream Cigarette Smoke

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2020

Authors: J. Edward; S. Coburn; C. Liu; J. Mcaughey; D. Mariner; K. G. McAdam; I. Bakos; S. Dobe
Product Type: Cigarettes
Study Type: Chemistry

GC x GC-TOFMS and chemometrics approach for comparative study of volatile compound release by tobacco heating system as a function of temperature

Microchemical Journal, 2020

Authors: T. G. Schwanz; M. G. Nespeca; J. C. Dias; L. V. V. Bokowski; M. C. A. Marcelo; D. H. Maximiano; L. S. Canova; P. B. de Souza Cruz; O. F. S. Pontes; S. Kaiser
Product Type: Heated Products
Study Type: Chemistry

Genotypic Variation in Nitrogen Use-Efficiency Traits of 28 Tobacco Genotypes

Agronomy - Basel, 2020

Authors: A. B. Andrade; D. R. Guelfi; V. Faquin; F. S. Coelho; C. S. D. Souza; G. P. Faquin; K. R. D. Souza; W. E. T. Chagas
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

In vitro biological assessment of the stability of cigarette smoke aqueous aerosol extracts

BMC Research Notes, 2020

Authors: M. Taylor; S. Santopietro; A. Baxter; N. East; D. Breheny; D. Thorne; M. Gaca
Product Type: Cigarettes
Study Type: Toxicology

Measures of dependence in menthol and nonmenthol smokers-A comprehensive narrative review

Journal of Addictive Diseases, 2020

Authors: K. Frost-Pineda; J. D. Heck; G. M. Curtin
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Optimization of aqueous aerosol extract (AqE) generation from e-cigarettes and tobacco heating products for in vitro cytotoxicity testing

Toxicology Letters, 2020

Authors: S. Bozhilova; A. Baxter; E. Bishop; D. Breheny; D. Thorne; P. Hodges; M Gaca
Product Type: Vapour Products, Heated Products
Study Type: Toxicology

Results from a 2018 cross-sectional survey in Tokyo, Osaka and Sendai to assess tobacco and nicotine product usage after the introduction of heated tobacco products (HTPs) in Japan

Harm Reduction Journal, 2020

Authors: J. Adamson; C. Kanitscheider; K. Prasad; O. M. Camacho; E. Beyerlein; Y. K. Bhagavan; C. Proctor; J. Murphy
Product Type: Heated Products, Cigarettes
Study Type: Consumer Use Behaviour

Skin sensitization in silico protocol

Regulatory Toxicology and Pharmacology, 2020

Authors: C. Johnson; E. Ahlberg; L. T. Anger; L. Beilke; R. Benigni; J. Bercu; S. Bobst; D. Bower; A. Brigo; S. Campbell; M. T. D. Cronini; I. Crooks; K. P. Cross; T. Doktorova; T. Exner; D. Faulkner; I. M. Fearon; M. Fehr; S. C. Gad; V. Gervais; A. Giddings; S. Glowienke; B. Hardy; C. Hasselgren; J. Hillegass; R. Jolly; E. Krupp; L. Lomnitski; J. Magby; J. Mestres; L. Milchak; S. Miller; W. Muster; L. Neilson; R. Parakhia; A. Parentys; P. Parris; A. Paulino; A. T. Paulino; D. W. Roberts; H. Schlecker; R. Stidl; D. Suarez-Rodrigez; D. T. Szabo; R. R. Tice; D. Urbisch; A. Vuorinen; B. Wall; T. Weiler; A. T. White; J. Whritenour; J. Wichard; D. Woolley; C. Zwickl; G. J. Myatt
Study Type: Toxicology

Statistical analysis plan for "A randomised, controlled study to evaluate the effects of switching from cigarette smoking to using a tobacco heating product on health effect indicators in healthy subjects"

Contemporary Clinical Trials Communications, 2020

Authors: O. M. Camacho; A. Hedge; F. Lowe; N. Newland; N. Gale; M. McEwan; C. Proctor
Product Type: Heated Products
Study Type: Clinical Studies

The evolving e-cigarette: comparative chemical analyses of e-cigarette vapor and cigarette smoke

Frontiers in Toxicology, 2020

Authors: A. Cunningham; K. McAdam; J. Thissen; H. Digard
Product Type: Vapour Products, Cigarettes
Study Type: Chemistry

The genotoxicological assessment of a tobacco heating product relative to cigarette smoke using the in vitro micronucleus assay

Toxicology Reports, 2020

Authors: D. Thorne; J. Whitwell; J. Clements; P. Walker; D. Breheny; M. Gaca
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

The in vitro assessment of a novel vaping technology

Toxicology Reports, 2020

Authors: D. Breheny; D. Thorne; A. Baxter; S. Bozhilova; T. Jaunky; S. Santopietro; M. Taylor; A. Terry; M. Gaca
Product Type: Vapour Products
Study Type: Toxicology

Variations of TSNA Levels in Tobaccos Upon Heating at Moderate Temperatures

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2020

Authors: S. C. Moldoveanu; M. Adams; F. K. St Charles
Product Type: Tobacco
Study Type: Chemistry

Workshop Series to Identify, Discuss, and Develop Recommendations for the Optimal Generation and Use of In Vitro Assay Data for Tobacco Product Evaluation: Phase 1 Genotoxicity Assays

Applied In Vitro Toxicology, 2020

Authors: M. M. Moore; J. Clements; P. Desai; U. Doshi; M. Gaca; X. Guo; T. Hashizume; K. G. Jordan; K. M. Lee; R. Leverette; D. McHugh; J. Miller-Holt; G. Phillips; H. Raabe; L. Recio; S. Roy; D. J. Smart; L. F. Stankowski; D. Thorne; E. Weber; R. Wieczorek; K. Yoshino; R. Curren
Study Type: Toxicology

Accelerated flowering time reduces lifetime water use without penalizing reproductive performance in Arabidopsis

Plant Cell and Environment, 2019

Authors: J. N. Ferguson; R. C. Meyer; K. D. Edwards; M. Humphry; O. Brendel; U. Bechtold
Study Type: Agronomy/Plant Biotechnology

Acetoin is a precursor to diacetyl in e-cigarette liquids

Food and Chemical Toxicology, 2019

Authors: C. A. Vas; A. Porter; K. McAdam
Product Type: Vapour Products
Study Type: Chemistry

An approach to testing undiluted e-cigarette aerosol in vitro using 3D reconstituted human airway epithelium

Toxicology in Vitro, 2019

Authors: E. Bishop; L. Haswell; J. Adamson; S. Costigan; D. Thorne; M. Gaca
Product Type: Vapour Products
Study Type: Toxicology

An inter-laboratory in vitro assessment of cigarettes and next generation nicotine delivery products

Toxicology Letters, 2019

Authors: S. Ito; M. Taylor; S. Mori; D. Thorne; T. Nishino; D. Breheny; M. Gaca; K. Yoshino; C. Proctor
Product Type: Vapour Products, Heated Products
Study Type: Toxicology

Analysis of chemosensory markers in cigarette smoke from different tobacco varieties by GC x GC-TOFMS and chemometrics

Talanta, 2019

Authors: T. G. Schwanz; L. V. V. Bokowski; M. C. A. Marcelo; A. C. Jandrey; J. C. Dias; D. H. Maximiano; L. S. Canova; O. F. S. Pontes; G. P. Sabin; S. Kaiser
Product Type: Cigarettes
Study Type: Consumer Impact Science

Assessment of priority tobacco additives per the requirements in the EU Tobacco Products Directive (2014/40/EU): Part 2: Smoke chemistry and in vitro toxicology

Regulatory Toxicology and Pharmacology, 2019

Authors: R. Stabbert; D. Ghosh; A. Clarke; J. Miller; J. Collard; I. Crooks; D. T. Djoko; S. Larroque; G. Jaccard; E. Roemer; C. H. Park; M. Esposito
Product Type: Cigarettes
Study Type: Chemistry, Toxicology

Assessment of priority tobacco additives per the requirements of the EU Tobacco Products Directive (2014/40/EU): Part 1: Background, approach, and summary of findings

Regulatory Toxicology and Pharmacology, 2019

Authors: L. Simms; A. Clarke; T. Paschke; A. Manson; J. Murphy; R. Stabbert; M. Esposito; D. Ghosh; E. Roemer; J. Martinez; J. Freiesleben; H. K. Kim; T. Lindegaard; M. Scharfe; I. Vincze; P. Vlachos; D. Wigotzki; G. Pollner; R. Lutz
Product Type: Cigarettes
Study Type: Chemistry, Toxicology

Assessment of priority tobacco additives per the requirements of the EU Tobacco Products Directive (2014/40/EU): Part 3, Smoking behavior and plasma nicotine pharmacokinetics

Regulatory Toxicology and Pharmacology, 2019

Authors: M. McEwan; S. Coburn; D. Ghosh; L. Simms; L. Giles; D. Yuki; M. Ashley; E. Roemer; H. O. Sohn; C. Proctor
Product Type: Cigarettes
Study Type: Consumer Use Behaviour, Clinical Studies

Biomarkers of Tobacco Exposure Decrease After Smokers Switch to an E-Cigarette or Nicotine Gum

Nicotine & Tobacco Research, 2019

Authors: E. K. Round; P. Chen; A. K. Taylor; E. Schmidt
Product Type: Oral Nicotine Products, Vapour Products
Study Type: Clinical Studies

Changes in Biomarkers of Exposure on Switching From a Conventional Cigarette to Tobacco Heating Products: A Randomized, Controlled Study in Healthy Japanese Subjects

Nicotine & Tobacco Research, 2019

Authors: N. Gale; M. McEwan; A. C. Eldridge; I. M. Fearon; N. Sherwood; E. Bowen; S. McDermott; E. Holmes; A. Hedge; S. Hossack; L. Wakenshaw; J. Glew; O. M. Camacho; G. Errington; J. McAughey; J. Murphy; C. Liu; C. J. Proctor
Product Type: Heated Products, Cigarettes
Study Type: Clinical Studies

Cigarette and ENDS preparations differentially regulate ion channels and mucociliary clearance in primary normal human bronchial 3D cultures

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2019

Authors: R. E. Rayner; P. Makena; G. L. Prasad; E. Cormet-Boyaka
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Cigarette smoke preparations, not moist snuff, impair expression of genes involved in immune signaling and cytolytic functions

Scientific Reports, 2019

Authors: G. Liu; S. Arimilli; E. Savage; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology

Combustible Cigarette and Smokeless Tobacco Product Preparations Differentially Regulate Intracellular Calcium Mobilization in HL60 Cells

Inflammation, 2019

Authors: S. Arimilli; P. Makena; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology

Development of a quantitative method for assessment of dose in in vitro evaluations using a VITROCELL® VC10® smoke exposure system

Toxicology in Vitro, 2019

Authors: Keyser, BM; Leverette, R; Fowler, K; Fields, W; Hargreaves, V; Reeve, L; Bombick, B
Product Type: Cigarettes
Study Type: Toxicology

Distinct gene expression changes in human peripheral blood mononuclear cells treated with different tobacco product preparations

Toxicology in Vitro, 2019

Authors: S. Arimilli; P. Makena; G. Liu; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Evaluating the effects of switching from cigarette smoking to using a heated tobacco product on health effect indicators in healthy subjects: study protocol for a randomized controlled trial

Internal and Emergency Medicine, 2019

Authors: N. Newland; F. J. Lowe; O. M. Camacho; M. McEwan; N. Gale; J. Ebajemito; G. Hardie; J. Murphy; C. Proctor
Product Type: Heated Products, Cigarettes
Study Type: Clinical Studies

Evaluation of an online, real-time, soft-photon ionisation time-of-flight mass spectrometer for mainstream tobacco smoke analysis

BMC Chemistry, 2019

Authors: J. Hawke; G. Errington; M. B. von Frowein
Product Type: Cigarettes
Study Type: Chemistry

Extraction from Moist Snuff with Artificial Saliva of Benzo[a]pyrene and Other Polycyclic Aromatic Hydrocarbons

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2019

Authors: S. C. Moldoveanu; J. W. Marshall; T. H. Poole
Product Type: Oral Tobacco Products
Study Type: Chemistry

Fast inline tobacco classification by near-infrared hyperspectral imaging and support vector machine-discriminant analysis

Analytical Methods, 2019

Authors: M. C. A. Marcelo; F. L. F. Soares; J. A. Ardila; J. C. Dias; R. Pedo; S. Kaiser; O. F. S. Pontes; C. E. Pulcinelli; G. P. Sabin
Product Type: Tobacco
Study Type: Chemistry

Genetic analysis of Phn7.1, a major QTL conferring partial resistance to Phytophthora nicotianae in Nicotiana tabacum

Molecular Breeding, 2019

Authors: J. M. Ma; C. Heim; M. Humphry; J. M. Nifong; R. S. Lewis
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Genetic Control of Facultative Parthenocarpy in Nicotiana tabacum L.

Journal of Heredity, 2019

Authors: Dexter-Boone, Abigail; Humphry, Matt; Shi, Rui; Lewis, Ramsey S.
Study Type: Agronomy/Plant Biotechnology

Genetic toxicology in silico protocol

Regulatory Toxicology and Pharmacology, 2019

Authors: C. Hasselgren; E. Ahlberg; Y. Akahori; A. Amberg; L. T. Anger; F. Atienzar; S. Auerbach; L. Beilke; P. Bellion; R. Benigni; J. Bercu; E. D. Booth; D. Bower; A. Brigo; Z. Cammerer; M. T. D. Cronin; I. Crooks; K. P. Cross; L. Custer; K. Dobo; T. Doktorova; D. Faulkner; K. A. Ford; M. C. Fortin; M. Frericks; S. E. Gad-McDonald; N. Gellatly; H. Gerets; V. Gervais; S. Glowienke; J. Van Gompel; J. S. Harvey; J. Hillegass; M. Honma; J. H. Hsieh; C. W. Hsu; T. S. Barton-Maclaren; C. Johnson; R. Jolly; D. Jones; R. Kemper; M. O. Kenyon; N. L. Kruhlak; S. A. Kulkarni; K. Kummerer; P. Leavitt; S. Masten; S. Miller; C. Moudgal; W. Muster; A. Paulino; E. Lo Piparo; M. Powley; D. P. Quigley; M. V. Reddy; A. N. Richarz; B. Schilter; R. D. Snyder; L. Stavitskaya; R. Stidl; D. T. Szabo; A. Teasdale; R. R. Tice; A. Trejo-Martin; A. Vuorinen; B. A. Wall; P. Watts; A. T. White; J. Wichard; K. L. Witt; A. Woolley; D. Woolley; C. Zwickl; G. J. Myatt
Study Type: Toxicology

Genotoxicity evaluation of tobacco and nicotine delivery products: Part One. Mouse lymphoma assay

Food and Chemical Toxicology, 2019

Authors: D. Thorne; R. Leverette; D. Breheny; M. Lloyd; S. McEnaney; J. Whitwell; J. Clements; B. Bombick; M. Gaca
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology

Genotoxicity evaluation of tobacco and nicotine delivery products: Part Two. In vitro micronucleus assay

Food and Chemical Toxicology, 2019

Authors: D. Thorne; R. Leverette; D. Breheny; M. Lloyd; S. McEnaney; J. Whitwell; J. Clements; B. Bombick; M. Gaca
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology

Global gene expression profiles from PBMCs treated with reference tobacco product preparations

Data in Brief, 2019

Authors: S. Arimilli; P. Makena; G. Liu; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology

Grafting of amine functions on cellulose acetate fibers by plasma processing

Reactive & Functional Polymers, 2019

Authors: M. Kajjout; Y. Lemmouchi; C. Jama; C. Rolando; F. Villasmunta; F. Heinrich; A. Mazzah
Study Type: Chemistry

In vitro mutagenicity of gas-Vapour Products phase extracts from flavoured and unflavoured heated tobacco products

Toxicology Reports, 2019

Authors: T. Le Godec; I. Crooks; K. Scott; C. Meredith
Product Type: Heated Products
Study Type: Toxicology

Influence of machine-based puffing parameters on aerosol and smoke emissions from next generation nicotine inhalation products

Regulatory Toxicology and Pharmacology, 2019

Authors: K. McAdam; P. Davis; L. Ashmore; D. Eaton; B. Jakaj; A. Eldridge; C. Liu
Product Type: Vapour Products, Heated Products
Study Type: Chemistry

Inline simultaneous quantitation of tobacco chemical composition by infrared hyperspectral image associated with chemometrics

Microchemical Journal, 2019

Authors: F. L. F. Soares; M. C. A. Marcelo; L. M. F. Porte; O. F. S. Pontes; S. Kaiser
Product Type: Tobacco
Study Type: Chemistry

Investigation of multiple whole smoke dosimetry techniques using a VITROCELL®VC10® smoke exposure system

Toxicology Reports, 2019

Authors: B. M. Keyser; R. Leverette; M. Hollings; A. Seymour; L. Reeve; W. Fields
Product Type: Cigarettes
Study Type: Toxicology

Investigation of number of replicate measurements required to meet cigarette smoke chemistry regulatory requirements measured under Canadian intense smoking conditions

Regulatory Toxicology and Pharmacology, 2019

Authors: A. Eldridge; T. Betson; M. V. Gama; G. Errington; K. McAdam
Product Type: Cigarettes
Study Type: Chemistry

Isolation and Purification of Pyrazines Produced by Reaction of Cellulosic-Derived Sugars with NH4OH and Selected Amino Acids

Journal of Chromatographic Science, 2019

Authors: M. Ashraf-Khorassani; W. M. Coleman; M. F. Dube; L. T. Taylor
Study Type: Chemistry

Mechanisms of whole smoke conditioned media induced cytotoxicity to human aortic endothelial cells

Toxicology in Vitro, 2019

Authors: P. Makwana; H. Flockton; G. A. Smith; G. P. Watters; R. Nisar; W. Fields
Product Type: Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Non-targeted analysis of the particulate phase of heated tobacco product aerosol and cigarette mainstream tobacco smoke by thermal desorption comprehensive two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection

Journal of Chromatography A, 2019

Authors: B. Savareear; J. Escobar-Arnanz; M. Brokl; M. J. Saxton; C. Wright; C. Liu; J. F. Focant
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Optimization of Normal Human Bronchial Epithelial (NHBE) Cell 3D Cultures for in vitro Lung Model Studies

Scientific Reports, 2019

Authors: R. E. Rayner; P. Makena; G. L. Prasad; E. Cormet-Boyaka
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Protocol for a Japanese nationwide repeated cross-sectional study to assess tobacco and nicotine product use behaviour after market introduction of tobacco heating products (THPs)

F1000Research, 2019

Authors: J. Adamson; C. Kanitscheider; K. Prasad; O. M. Camacho; E. Beyerlein; Y. Keralapura; C. Proctor; J. Murphy
Product Type: Heated Products
Study Type: Consumer Use Behaviour

Randomized Trial to Compare Smoking Cessation Rates of Snus, With and Without Smokeless Tobacco Health-Related Information, and a Nicotine Lozenge

Nicotine & Tobacco Research, 2019

Authors: P. R. Nelson; P. Chen; D. R. Battista; J. L. Pillitteri; S. Shiffman
Product Type: Oral Tobacco Products, Oral Nicotine Products
Study Type: Clinical Studies, Consumer Use Behaviour

Sources of Nonlinear van't Hoff Temperature Dependence in High-Performance Liquid Chromatography

ACS Omega, 2019

Authors: M. Tanase; A. Soare; V. David; S. C. Moldoveanu
Study Type: Chemistry

Targeting Acr3 from Ensifer medicae to the plasma membrane or to the tonoplast of tobacco hairy roots allows arsenic extrusion or improved accumulation. Effect of acr3 expression on the root transcriptome

Metallomics, 2019

Authors: P. Perez-Palacios; I. Funes-Pinter; E. Agostini; M. A. Talano; S. G. Ibanez; M. Humphry; K. Edwards; I. D. Rodriguez-Llorente; M. A. Caviedes; E. Pajuelo
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

The composition of contemporary American and Swedish smokeless tobacco products

BMC Chemistry, 2019

Authors: K. G. McAdam; H. Kimpton; A. Faizi; A. Porter; B. Rodu
Product Type: Oral Tobacco Products
Study Type: Chemistry

Tolerance and overcompensation to infection by Phytophthora infestans in the wild perennial climber Solanum dulcamara

Ecology and Evolution, 2019

Authors: L. Masini; L. J. Grenville-Briggs; E. Andreasson; L. Raberg; A. Lankinen
Study Type: Agronomy/Plant Biotechnology

Urinary leukotriene E4 and 2, 3-dinor thromboxane B2 are biomarkers of potential harm in short-term tobacco switching studies

Cancer Epidemiology, Biomarkers & Prevention, 2019

Authors: P. Makena; G. Liu; P. Chen; C. R. Yates; G. Prasad
Product Type: Oral Tobacco Products, Vapour Products, Cigarettes
Study Type: Clinical Studies

Use of social media to establish vapers puffing behaviour: Findings and implications for laboratory evaluation of e-cigarette emissions

Regulatory Toxicology and Pharmacology, 2019

Authors: K. McAdam; A. Warrington; A. Hughes; D. Adams; J. Margham; C. Vas; P. Davis; S. Costigan; C. Proctor
Product Type: Vapour Products
Study Type: Consumer Use Behaviour

Variation with temperature of octanol/water partition coefficient for the homologous series from benzene to propylbenzene

Separation Science Plus, 2019

Authors: V. David; S. C. Moldoveanu
Study Type: Chemistry

Fast inline tobacco classification by near-infrared hyperspectral imaging and support vector machine-discriminant analysis

Analytical Methods, 2019

Authors: M. C. A. Marcelo; F. L. F. Soares; J. A. Ardila; J. C. Dias; R. Pedo; S. Kaiser; O. F. S. Pontes; C. E. Pulcinelli; G. P. Sabin
Product Type: Tobacco
Study Type: Chemistry

Analysis of chemosensory markers in cigarette smoke from different tobacco varieties by GC×GC-TOFMS and chemometrics

Talanta, 2019

Authors: T. G. Schwanz; L. V. V. Bokowski; M. C. A. Marcelo; A. C. Jandrey; J. C. Dias; D. H. Maximiano; L. S. Canova; O. F. S. Pontes; G. P. Sabin; S. Kaiser
Product Type: Cigarettes
Study Type: Consumer Impact Science

Inline simultaneous quantitation of tobacco chemical composition by infrared hyperspectral image associated with chemometrics

Microchemical Journal, 2019

Authors: F. L. F. Soares; M. C. A. Marcelo; L. M. F. Porte; O. F. S. Pontes; S. Kaiser
Product Type: Tobacco
Study Type: Chemistry

A Case Study for the Comparison of In Vitro Data Across Multiple Aerosol Exposure Studies with Extrapolation to Human Dose

Applied In Vitro Toxicology, 2018

Authors: D. Thorne; E. Bishop; L. E. Haswell; M. Gaca
Product Type: Cigarettes
Study Type: Toxicology

A review of electronic cigarette use behaviour studies

Contributions to Tobacco & Nicotine Research, 2018

Authors: X. Cahours; K. Prasad
Product Type: Vapour Products
Study Type: Consumer Use Behaviour

Accurate measurement of main aerosol constituents from heated tobacco products (HTPs): Implications for a fundamentally different aerosol

Regulatory Toxicology and Pharmacology, 2018

Authors: H. Gasparyan; D. Mariner; C. Wright; J. Nicol; J. Murphy; C. Liu; C. Proctor
Product Type: Heated Products
Study Type: Chemistry

Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report

Toxicology in Vitro, 2018

Authors: A. J. Clippinger; D. Allen; A. M. Jarabek; M. Corvaro; M. Gaca; S. Gehen; J. A. Hotchkiss; G. Patlewicz; J. Melbourne; P. Hinderliter; M. Yoon; D. Huh; A. Lowit; B. Buckley; M. Bartels; K. BeruBe; D. M. Wilson; I. Indans; M. Vinken
Study Type: Toxicology

An LC-MS Method for the Analysis of Some Organic Acids in Tobacco Leaf, Snus, and Wet Snuff

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2018

Authors: S. C. Moldoveanu; T. Poole; W. A. Scott
Product Type: Oral Tobacco Products, Cigarettes, Tobacco
Study Type: Chemistry

Analysis of coumarin and angelica lactones in smokeless tobacco products

Chemistry Central Journal, 2018

Authors: K. McAdam; T. Enos; C. Goss; H. Kimpton; A. Faizi; S. Edwards; C. Wright; A. Porter; B. Rodu
Product Type: Oral Tobacco Products
Study Type: Chemistry

Assessing the Likelihood and Magnitude of a Population Health Benefit Following the Market Introduction of a Modified-Risk Tobacco Product: Enhancements to the Dynamic Population Modeler, DPM(+1)

Risk Analysis, 2018

Authors: A. M. Bachand; S. I. Sulsky; G. M. Curtin
Product Type: Oral Nicotine Products, Oral Tobacco Products, Vapour Products, Heated Products
Study Type: Population Health Impact

Assessment of enamel discoloration in vitro following exposure to cigarette smoke and emissions from novel vapor and tobacco heating products

American Journal of Dentistry, 2018

Authors: A. Dalrymple; T. C. Badrock; A. Terry; M. Barber; P. J. Hall; D. Thorne; M. D. Gaca; S. Coburn; C. Proctor
Product Type: Vapour Products
Study Type: Consumer Impact Science

Assessment of novel tobacco heating product THP1.0. Part 3: Comprehensive chemical characterisation of harmful and potentially harmful aerosol emissions

Regulatory Toxicology and Pharmacology, 2018

Authors: M. Forster; S. Fiebelkorn; C. Yurteri; D. Mariner; C. Liu; C. Wright; K. McAdam; J. Murphy; C. Proctor
Product Type: Heated Products
Study Type: Chemistry

Assessment of novel tobacco heating product THP1.0. Part 6: A comparative in vitro study using contemporary screening approaches

Regulatory Toxicology and Pharmacology, 2018

Authors: M. Taylor; D. Thorne; T. Carr; D. Breheny; P. Walker; C. Proctor; M. Gaca
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Assessment of novel tobacco heating product THP1.0. Part 7: Comparative in vitro toxicological evaluation

Regulatory Toxicology and Pharmacology, 2018

Authors: D. Thorne; D. Breheny; C. Proctor; M. Gaca
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Assessment of the abuse liability of three menthol Vuse Solo electronic cigarettes relative to combustible cigarettes and nicotine gum

Psychopharmacology, 2018

Authors: M. F. Stiles; L. R. Campbell; T. Jin; D. W. Graff; R. V. Fant; J. E. Henningfield
Product Type: Vapour Products, Cigarettes
Study Type: Clinical Studies

Assessment of tobacco heating product THP1.0. Part 1: Series introduction

Regulatory Toxicology and Pharmacology, 2018

Authors: C. Proctor
Product Type: Heated Products

Assessment of tobacco heating product THP1.0. Part 2: Product design, operation and thermophysical characterisation

Regulatory Toxicology and Pharmacology, 2018

Authors: D. Eaton; B. Jakaj; M. Forster; J. Nicol; E. Mavropoulou; K. Scott; C. Liu; K. McAdam; J. Murphy; C. J. Proctor
Product Type: Heated Products
Study Type: Chemistry

Assessment of tobacco heating product THP1.0. Part 4: Characterisation of indoor air quality and odour

Regulatory Toxicology and Pharmacology, 2018

Authors: M. Forster; J. McAughey; K. Prasad; E. Mavropoulou; C. Proctor
Product Type: Heated Products
Study Type: Chemistry

Assessment of tobacco heating product THP1.0. Part 5: In vitro dosimetric and cytotoxic assessment

Regulatory Toxicology and Pharmacology, 2018

Authors: T. Jaunky; J. Adamson; S. Santopietro; A. Terry; D. Thorne; D. Breheny; C. Proctor; M. Gaca
Product Type: Heated Products
Study Type: Toxicology

Assessment of tobacco heating product THP1.0. Part 8: Study to determine puffing topography, mouth level exposure and consumption among Japanese users

Regulatory Toxicology and Pharmacology, 2018

Authors: J. Gee; K. Prasad; S. Slayford; A. Gray; K. Nother; A. Cunningham; E. Mavropoulou; C. Proctor
Product Type: Heated Products
Study Type: Consumer Use Behaviour

Assessment of tobacco heating product THP1.0. Part 9: The placement of a range of next-generation products on an emissions continuum relative to cigarettes via pre-clinical assessment studies

Regulatory Toxicology and Pharmacology, 2018

Authors: J. Murphy; C. Liu; K. McAdam; M. Gaca; K. Prasad; O. Camacho; J. McAughey; C. Proctor
Product Type: Heated Products, Vapour Products, Cigarettes
Study Type: Toxicology

Characterisation of the borgwaldt LM4E system for in vitro exposures to undiluted aerosols from next generation tobacco and nicotine products (NGPs)

Food and Chemical Toxicology, 2018

Authors: J. Adamson; T. Jaunky; D. Thorne; M. D. Gaca
Product Type: Vapour Products, Heated Products
Study Type: Toxicology

Characterization of a Vitrocell VC1 Using Nicotine Dosimetry: An Essential Component Toward Standardized In Vitro Aerosol Exposure of Tobacco and Next Generation Nicotine Delivery Products

Applied In Vitro Toxicology, 2018

Authors: H. Behrsing; M. Aragon; J. Adamson; D. Sheehan; M. Gaca; R. Curren; E. Hill
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology

Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase

Nitric Oxide-Biology and Chemistry, 2018

Authors: T. M. Abdelghany; R. S. Ismail; F. A. Mansoor; J. R. Zweier; F. Lowe; J. L. Zweier
Product Type: Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Comprehensive comparative compositional study of the Vapour Products phase of cigarette mainstream tobacco smoke and tobacco heating product aerosol

Journal of Chromatography A, 2018

Authors: B. Savareear; J. Escobar-Arnanz; M. Brokl; M. J. Saxton; C. Wright; C. Liu; J. F. Focant
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Critical evaluation of several techniques for the analysis of phthalates and terephthalates: Application to liquids used in electronic cigarettes

Journal of Chromatography A, 2018

Authors: S. C. Moldoveanu; R. Yerabolu
Product Type: Vapour Products
Study Type: Chemistry

Development, qualification, validation and application of the Ames test using a VITROCELL® VC10® smoke exposure system

Toxicology Reports, 2018

Authors: K. Fowler; W. Fields; V. Hargreaves; L. Reeve; B. Bombick
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Effect of temperature and humidity on the gas-particle partitioning of nicotine in mainstream cigarette smoke: A diffusion denuder study

Journal of Aerosol Science, 2018

Authors: E. John; S. Coburn; C. Liu; J. McAughey; D. Mariner; K. G. McAdam; Z. Sebestyen; I. Bakos; S. Dobe
Product Type: Cigarettes
Study Type: Aerosol Physics

Estimation of the Leukemia Risk in Human Populations Exposed to Benzene from Tobacco Smoke Using Epidemiological Data

Risk Analysis, 2018

Authors: S. Fiebelkorn; C. Meredith
Product Type: Cigarettes
Study Type: Population Health Impact

Ethyl carbamate in Swedish and American smokeless tobacco products and some factors affecting its concentration

Chemistry Central Journal, 2018

Authors: K. McAdam; C. Vas; H. Kimpton; A. Faizi; C. Liu; A. Porter; T. Synnerdahl; P. Karlsson; B. Rodu
Product Type: Oral Tobacco Products
Study Type: Chemistry

Evaluation of flavourings potentially used in a heated tobacco product: Chemical analysis, in vitro mutagenicity, genotoxicity, cytotoxicity and in vitro tumour promoting activity

Food and Chemical Toxicology, 2018

Authors: I. Crooks; L. Neilson; K. Scott; L. Reynolds; T. Oke; M. Forster; C. Meredith; K. McAdam; C. Proctor
Product Type: Heated Products
Study Type: Toxicology

Extreme testing of undiluted e-cigarette aerosol in vitro using an Ames air-agar-interface technique

Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2018

Authors: D. Thorne; M. Hollings; A. Seymour; J. Adamson; A. Dalrymple; M. Ballantyne; M. Gaca
Product Type: Vapour Products
Study Type: Toxicology

Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice

Food and Chemical Toxicology, 2018

Authors: M. Liu; C. C. Key; A. Weckerle; E. Boudyguina; J. K. Sawyer; A. K. Gebre; W. Spoo; O. Makwana; J. S. Parks
Product Type: Nicotine, Tobacco

Fractionation of cadmium in tobacco and cigarette smoke condensate using XANES and sequential leaching with ICP-MS/MS

Analytical and Bioanalytical Chemistry, 2018

Authors: S. Cuello-Nunez; J. Benning; C. Liu; P. Branton; J. Hu; K. G. McAdam; S. Coburn; J. Braybrook; H. Goenaga-Infante
Product Type: Cigarettes
Study Type: Chemistry

Global methylation profiles in buccal cells of long-term smokers and moist snuff consumers

Biomarkers, 2018

Authors: W. J. Jessen; M. F. Borgerding; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment, Clinical Studies

Human In Vitro models for respiratory toxicology: evaluation of goblet cell hyperplasia, mucus production, and ciliary beating assays

Toxicology Letters, 2018

Authors: B. Gilbert; E. Hill; M. Aragon; S. Frentzel; J. Hoeng; S. Ito; S. Ishikawa; J. Budde; A. G. Maione; . Hayden; W. Fields; B. Keyser; L. E. Haswell; D. Azzopardi; H. Behrsing
Study Type: Toxicology

Identification of volatiles from heated tobacco biomass using direct thermogravimetric analysis-Mass spectrometry and target factor analysis

Thermochimica Acta, 2018

Authors: A. Davies; J. T. G. Nicol; C. Liu; J. Tetteh; K. McAdam
Product Type: Tobacco
Study Type: Chemistry

In silico toxicology protocols

Regulatory Toxicology and Pharmacology, 2018

Authors: G. J. Myatt; E. Ahlberg; Y. Akahori; D. Allen; A. Amberg; L. T. Anger; A. Aptula; S. Auerbach; L. Beilke; P. Bellion; R. Benigni; J. Bercu; E. D. Booth; D. Bower; A. Brigo; N. Burden; Z. Cammerer; M. T. D. Cronin; K. P. Cross; L. Custer; M. Dettwiler; K. Dobo; K. A. Ford; M. C. Fortin; S. E. Gad-McDonald; N. Gellatly; V. Gervais; K. P. Glover; S. Glowienke; J. Van Gompel; S. Gutsell; B. Hardy; J. S. Harvey; J. Hillegass; M. Honma; J. H. Hsieh; C. W. Hsu; K. Hughes; C. Johnson; R. Jolly; D. Jones; R. Kemper; M. O. Kenyon; M. T. Kim; N. L. Kruhlak; S. A. Kulkarni; K. Kummerer; P. Leavitt; B. Majer; S. Masten; S. Miller; J. Moser; M. Mumtaz; W. Muster; L. Neilson; T. I. Oprea; G. Patlewicz; A. Paulino; E. Lo Piparo; M. Powley; D. P. Quigley; M. V. Reddy; A. N. Richarz; P. Ruiz; B. Schilter; R. Serafimova; W. Simpson; L. Stavitskaya; R. Stidl; D. Suarez-Rodriguez; D. T. Szabo; A. Teasdale; A. Trejo-Martin; J. P. Valentin; A. Vuorinen; B. A. Wall; P. Watts; A. T. White; J. Wichard; K. L. Witt; A. Woolley; D. Woolley; C. Zwickl; C. Hasselgren
Study Type: Toxicology

In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke

Scientific Reports, 2018

Authors: L. E. Haswell; S. Corke; I. Verrastro; A. Baxter; A. Banerjee; J. Adamson; T. Jaunky; C. Proctor; M. Gaca; E. Minet
Product Type: Heated Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non tobacco consumers

Cytokine, 2018

Authors: J. A. Sgambato; B. A. Jones; J. W. Caraway; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Clinical Studies, Preclinical/In Vitro Disease Assessment

Integrating chemical, toxicological and clinical research to assess the potential of reducing health risks associated with cigarette smoking through reducing toxicant emissions

Regulatory Toxicology and Pharmacology, 2018

Authors: K. McAdam; J. Murphy; A. Eldridge; C. Meredith; C. Proctor
Product Type: Cigarettes
Study Type: Chemistry, Toxicology, Clinical Studies

Integration of time and spatially resolved in-situ temperature and pressure measurements with soft ionisation mass spectrometry inside a burning superslim cigarette

Journal of Analytical and Applied Pyrolysis, 2018

Authors: H. P. Cui; S. Ehlert; F. W. Xie; J. Heide; N. Deng; B. Li; C. Liu; K. McAdam; A. Walte; R. Zimmermann
Product Type: Cigarettes
Study Type: Aerosol Physics, Chemistry

Next-generation tobacco and nicotine products: Substantiating harm reduction and supporting tobacco regulatory science

Toxicology Research and Application, 2018

Authors: M. C. Peitsch; R. Polosa; C. Proctor; T. Hassler; M. Gaca; E. Hill; J. Hoeng; A. W. Hayes
Product Type: Oral Nicotine Products, Oral Tobacco Products, Vapour Products, Heated Products

Nicotine pharmacokinetics of electronic cigarettes: A review of the literature

Regulatory Toxicology and Pharmacology, 2018

Authors: I. M. Fearon; A. C. Eldridge; N. Gale; M. McEwan; M. F. Stiles; E. K. Round
Product Type: Vapour Products
Study Type: Clinical Studies

Optimized method for determination of 16 FDA polycyclic aromatic hydrocarbons (PAHs) in mainstream cigarette smoke by gas chromatography-mass spectrometry

Chemistry Central Journal, 2018

Authors: J. Jeffery; M. Carradus; K. Songin; M. Pettit; K. Pettit; C. Wright
Product Type: Cigarettes
Study Type: Chemistry

Outcomes of developmental exposure to total particulate matter from cigarette smoke in zebrafish (Danio rerio)

Neurotoxicology, 2018

Authors: A. Massarsky; N. Jayasundara; L. Glazer; E. D. Levin; G. L. Prasad; R. T. Di Giulio
Product Type: Cigarettes
Study Type: Toxicology

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

Toxicology in Vitro, 2018

Authors: A. J. Clippinger; D. Allen; H. Behrsing; K. A. BeruBe; M. B. Bolger; W. Casey; M. DeLorme; M. Gaca; S. C. Gehen; K. Glover; P. Hayden; P. Hinderliter; J. A. Hotchkiss; A. Iskandar; B. Keyser; K. Luettich; L. Ma-Hock; A. G. Maione; P. Makena; J. Melbourne; L. Milchak; S. P. Ng; A. Paini; K. Page; G. Patlewicz; P. Prieto; H. Raabe; E. N. Reinke; C. Roper; J. Rose; M. Sharma; W. Spoo; P. S. Thorne; D. M. Wilson; A. M. Jarabek
Study Type: Preclinical / In Vitro Disease Assessment, Toxicology

Plant immunity in natural populations and agricultural fields: Low presence of pathogenesis-related proteins in Solanum leaves

PLOS One, 2018

Authors: A. Lankinen; K. B. Abreha; L. Masini; A. Ali; S. Resjo; E. Andreasson
Study Type: Agronomy/Plant Biotechnology

Pyroxasulfone resistance in Lolium rigidum is metabolism-based

Pesticide Biochemistry and Physiology, 2018

Authors: R. Busi; A. Porri; T. A. Gaines; S. B. Powles
Study Type: Agronomy/Plant Biotechnology

Quantitative risk assessment of tobacco products: A potentially useful component of substantial equivalence evaluations

Regulatory Toxicology and Pharmacology, 2018

Authors: K. M. Marano; C. Liu; W. Fuller; P. R. Gentry
Study Type: Toxicology

Results from solvophobic theory applied to methylene selectivity in reversed-phase HPLC

Journal of Liquid Chromatography & Related Technologies, 2018

Authors: S. C. Moldoveanu; E. Caiali; V. David
Study Type: Chemistry

Suppression of Neutrophil Antimicrobial Functions by Total Particulate Matter From Cigarette Smoke

Frontiers in Immunology, 2018

Authors: Y. Zhang; S. Geng; G. L. Prasad; L. Li
Product Type: Cigarettes
Study Type: Toxicology

Thermo-oxidative decomposition of lime, bergamot and cardamom essential oils

Journal of Analytical and Applied Pyrolysis, 2018

Authors: E. Jakab; M. Blazso; E. Barta-Rajnai; B. Babinszki; Z. Sebestyen; Zs. Czegeny; J. Nicol; P. Clayton; K. McAdam; C. Liu
Study Type: Chemistry

Thermo-oxidative degradation of aromatic flavour compounds under simulated tobacco heating product condition

Journal of Analytical and Applied Pyrolysis, 2018

Authors: M. Blazso; B. Babinszki; Z. Czegeny; E. Barta-Rajnai; Z. Sebestyen; E. Jakab; J. Nicol; C. Liu; K. McAdam
Product Type: Heated Products
Study Type: Chemistry

Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio)

Toxicology and Applied Pharmacology, 2018

Authors: A. Massarsky; G. L. Prasad; R. T. Di Giulio
Product Type: Cigarettes
Study Type: Toxicology

High-throughput simultaneous quantitation of multi-analytes in tobacco by flow injection coupled to high-resolution mass spectrometry

Talanta, 2018

Authors: S. Kaiser; J. C. Dias; J. A. Ardila; F. L. F. Soares; M. C. A. Marcelo; L. M. F. Porte; C. Gonçalves; L. D. S. Canova; O. F. S. Pontes; G. P. Sabin
Product Type: Tobacco
Study Type: Chemistry

Innovative Approaches for Estimating the Levels of Tobacco-Specific Nitrosamines in Cured Tobacco Samples

Chemical Research in Toxicology, 2018

Authors: S. Kaiser; F. L. F. Soares; J. A. Ardila; M. C. A. Marcelo; J. C. Dias; L. M. F. Porte; C. Goncalves; O. F. S. Pontes; G. P. Sabin
Product Type: Tobacco
Study Type: Chemistry

A comparative assessment of e-cigarette aerosols and cigarette smoke on in vitro endothelial cell migration

Toxicology Letters, 2017

Authors: M. Taylor; T. Jaunky; K. Hewitt; D. Breheny; F. Lowe; I. M. Fearon; M. Gaca
Product Type: Vapour Products, Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

A mini-literature review on the science of tobacco heating product THP1.0

Tobacco Science & Technology, 2017

Authors: D. Thorne; D. Breheny; M. Gaca; C. Liu; J. Murphy; C. Proctor
Product Type: Heated Products

A novel hybrid tobacco product that delivers a tobacco flavour note with Vapour Products aerosol (Part 1): Product operation and preliminary aerosol chemistry assessment

Food and Chemical Toxicology, 2017

Authors: S. Poynton; J. Sutton; S. Goodall; J. Margharn; M. Forster; K. Scott; C. Liu; K. McAdam; J. Murphy; C. Proctor
Product Type: Vapour Products
Study Type: Chemistry

A novel hybrid tobacco product that delivers a tobacco flavour note with Vapour Products aerosol (Part 2): In vitro biological assessment and comparison with different tobacco-heating products

Food and Chemical Toxicology, 2017

Authors: D. Breheny; J. Adamson; D. Azzopardi; A. Baxter; E. Bishop; T. Carr; I. Crooks; K. Hewitt; T. Jaunky; S. Larard; F. Lowe; O. Oke; M. Taylor; S. Santopietro; D. Thorne; B. Zainuddin; M. Gaca; C. Liu; J. Murphy; C. Proctor
Product Type: Vapour Products, Heated Products, Cigarettes
Study Type: Toxicology

A pharmacokinetic study to examine nicotine delivery from e cigarettes and a conventional cigarette in healthy subjects during a brief period of ad libitum use

International Journal of Clinical Trials, 2017

Authors: I. M. Fearon; M. Nides; A. Eldridge; O. M. Camacho; J. Murphy; C. J. Proctor
Product Type: Vapour Products
Study Type: Clinical Studies

A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product

BMC Public Health, 2017

Authors: N. Gale; M. McEwan; A. C. Eldridge; N. Sherwood; E. Bowen; S. McDermott; E. Holmes; A. Hedge; S. Hossack; O. M. Camacho; G. Errington; J. McAughey; J. Murphy; C. Liu; C. J. Proctor; I. M. Fearon
Product Type: Heated Products
Study Type: Clinical Studies

A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci implicated in nitrogen utilization efficiency

BMC Genomics, 2017

Authors: K. D. Edwards; N. Fernandez-Pozo; K. Drake-Stowe; M. Humphry; A. D. Evans; A. Bombarely; F. Allen; R. Hurst; B. White; S. P. Kernodle; J. R. Bromley; J. P. Sanchez-Tamburrino; R. S. Lewis; L. A. Mueller
Study Type: Agronomy/Plant Biotechnology

A system dynamics modelling approach to assess the impact of launching a new nicotine product on population health outcomes

Regulatory Toxicology and Pharmacology, 2017

Authors: A. Hill; O. M. Camacho
Product Type: Vapour Products
Study Type: Population Health Impact

AKR1C1 as a Biomarker for Differentiating the Biological Effects of Combustible from Non-Combustible Tobacco Products

Genes, 2017

Authors: S. Woo; H. Gao; D. Henderson; W. Zacharias; G. Liu; Q. T. Tran; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

An approach to allergy risk assessments for e-liquid ingredients

Regulatory Toxicology and Pharmacology, 2017

Authors: S. Costigan; J. Lopez-Belmonte
Product Type: Vapour Products
Study Type: Toxicology

An Innovative Technique for Rapid Screening of Cigarette Filter Adsorbents

Chemical Engineering & Technology, 2017

Authors: P. Branton; M. Leistner; M. Wollner; S. Kaskel
Product Type: Cigarettes
Study Type: Chemistry

Analysis of Traces of Tobacco-Specific Nitrosamines (TSNAs) in USP Grade Nicotine, E-Liquids, and Particulate Phase Generated by the Electronic Smoking Devices

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2017

Authors: S. C. Moldoveanu; A. G. Hudson; A. Harrison
Product Type: Vapour Products
Study Type: Chemistry

Application of In Vitro Toxicology Approaches for the Evaluation of Next-Generation Nicotine Products

Applied In Vitro Toxicology, 2017

Authors: M. D. Gaca
Product Type: Vapour Products
Study Type: Toxicology

Assessing modified risk tobacco and nicotine products: Description of the scientific framework and assessment of a closed modular electronic cigarette

Regulatory Toxicology and Pharmacology, 2017

Authors: J. Murphy; M. Gaca; F. Lowe; E. Minet; D. Breheny; K. Prasad; O. Camacho; I. M. Fearon; C. Liu; C. Wright; K. McAdam; C. Proctor
Product Type: Vapour Products

Assessment of Acute In Vitro Human Cellular Responses to Smoke Extracts from a Reduced Toxicant Prototype Cigarette

Applied In Vitro Toxicology, 2017

Authors: O. Oke; D. Azzopardi; S. Corke; K. Hewitt; T. Carr; N. Cockcroft; G. Foss-Smith; M. Taylor; F. Lowe
Product Type: Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Characterization and Application of the VITROCELL VC1 Smoke Exposure System and 3D EpiAirway Models for Toxicological and e-Cigarette Evaluations

Applied In Vitro Toxicology, 2017

Authors: W. Fields; A. Maione; B. Keyser; B. Bombick
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Chemical characterisation of aerosols emitted by electronic cigarettes using thermal desorption - gas chromatography - time of flight mass spectrometry

Journal of Chromatography A, 2017

Authors: C. Rawlinson; S. Martin; J. Frosina; C. Wright
Product Type: Vapour Products
Study Type: Chemistry

Cigarette smoke extract counteracts atheroprotective effects of high laminar flow on endothelial function

Redox Biology, 2017

Authors: S. Giebe; N. Cockcroft; K. Hewitt; M. Brux; A. Hofmann; H. Morawietz; C. Brunssen
Product Type: Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

Comparative Tumor Promotion Assessment of e-Cigarette and Cigarettes Using the In Vitro Bhas 42 Cell Transformation Assay

Environmental and Molecular Mutagenesis, 2017

Authors: D. Breheny; O. Oke; K. Pant; M. Gaca
Product Type: Vapour Products
Study Type: Preclinical / In Vitro Disease Assessment

Comprehensive survey of radionuclides in contemporary smokeless tobacco products

Chemistry Central Journal, 2017

Authors: K. McAdam; H. Kimpton; A. Porter; C. Liu; A. Faizi; M. Mola; J. McAughey; B. Rodu
Product Type: Oral Tobacco Products
Study Type: Chemistry

Data on cardiovascular and pulmonary diseases among smokers of menthol and non-menthol cigarettes compiled from the National Health and Nutrition Examination Survey (NHANES), 1999-2012

Data in Brief, 2017

Authors: C. Van Landingham; W. Fuller; G. Mariano; K. Marano; G. Curtin; S. I. Sulsky
Product Type: Cigarettes
Study Type: Consumer Use Behaviour, Preclinical/In Vitro Disease Assessment

Development of an Adverse Outcome Pathway for the Onset of Hypertension by Oxidative Stress-Mediated Perturbation of Endothelial Nitric Oxide Bioavailability

Applied In Vitro Toxicology, 2017

Authors: F. J. Lowe; K. Luettich; M. Talikka; V. Hoang; L. E. Haswell; J. Hoeng; M. D. Gaca
Study Type: Preclinical / In Vitro Disease Assessment

Development, qualification, validation and application of the neutral red uptake assay in Chinese Hamster Ovary (CHO) cells using a VITROCELL VC10® smoke exposure system

Toxicology in Vitro, 2017

Authors: W. Fields; K. Fowler; V. Hargreaves; L. Reeve; B. Bombick
Study Type: Toxicology

Differential gene expression using RNA sequencing profiling in a reconstituted airway epithelium exposed to conventional cigarette smoke or electronic cigarette aerosols

Applied In Vitro Toxicology, 2017

Authors: A. Banerjee; L. E. Haswell; A. Baxter; A. Parmar; D. Azzopardi; S. Corke; D. Thorne; J. Adamson; J. Mushonganono; M. D. Gaca
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

E-cigarette Nicotine Delivery: Data and Learnings from Pharmacokinetic Studies

American Journal of Health Behavior, 2017

Authors: I. M. Fearon; A. Eldridge; N. Gale; C. J. Shepperd; M. McEwan; O. M. Camacho; M. Nides; K. McAdam; C. J. Proctor
Product Type: Vapour Products
Study Type: Clinical Studies

Enzymatic Systems for Cellulose Acetate Degradation

Catalysts, 2017

Authors: O. Haske-Cornelius; A. Pellis; G. Tegl; S. Wurz; B. Saake; R. Ludwig; A. Sebastian; G. S. Nyanhongo; G. M. Guebitz
Product Type: Cigarettes
Study Type: Chemistry

Gene expression profiles associated with cigarette smoking and moist snuff consumption

BMC Genomics, 2017

Authors: S. Arimilli; B. Madahian; P. Chen; K. Marano; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology

Headspace solid-phase microextraction coupled to comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the analysis of aerosol from tobacco heating product

Journal of Chromatography A, 2017

Authors: B. Savareear; R. Lizak; M. Brokl; C. Wright; C. Liu; J. F. Focant
Product Type: Heated Products
Study Type: Chemistry

Human Aortic Endothelial Cells Respond to Shear Flow in Well-Plate Microfluidic Devices

Atla-Alternatives to Laboratory Animals, 2017

Authors: O. Makwana; H. Flockton; G. P. Watters; R. Nisar; G. A. Smith; W. Fields; B. Bombick
Study Type: Preclinical / In Vitro Disease Assessment

Il-10 deficient mice express IFN-? mRNA and clear Leptospira interrogans from their kidneys more rapidly than normal C57BL/6 mice

Immunobiology, 2017

Authors: A. A. Devlin; P. J. Halvorsen; J. C. Miller; S. M. Laster
Study Type: Toxicology

Impact assessment of WHO TobReg proposals for mandated lowering of selected mainstream cigarette smoke toxicants

Regulatory Toxicology and Pharmacology, 2017

Authors: A. C. Eldridge; K. G. McAdam; T. R. Betson; M. V. Gama; C. J. Proctor
Product Type: Cigarettes
Study Type: Chemistry

In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use

Atla-Alternatives to Laboratory Animals, 2017

Authors: H. Behrsing; E. Hill; H. Raabe; R. Tice; S. Fitzpatrick; R. Devlin; K. Pinkerton; G. Oberdorster; C. Wright; R. Wieczorek; M. Aufderheide; S. Steiner; T. Krebs; B. Asgharian; R. Corley; M. Oldham; J. Adamson; X. Li; I. Rahman; S. Grego; P. H. Chu; S. McCullough; R. Curren
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology

Influence of cigarette filter ventilation on smokers' mouth level exposure to tar and nicotine

Regulatory Toxicology and Pharmacology, 2017

Authors: J. W. Caraway; M. Ashley; S. A. Bowman; P. Chen; G. Errington; K. Prasad; P. R. Nelson; C. J. Shepperd; I. M. Fearon
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures

Journal of Visualized Experiments: JoVE, 2017

Authors: A. Baxter; E. Minet
Study Type: Toxicology

Metabolic engineering of anthocyanins in dark tobacco varieties

Physiologia Plantarum, 2017

Authors: X. Z. He; Y. Li; D. Lawson; D. Y. Xie
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Nicotine quantification in vitro: a consistent dosimetry marker for e-cigarette aerosol and cigarette smoke generation

Applied In Vitro Toxicology, 2017

Authors: J. Adamson; X. Li; H. Cui; D. Thorne; F. Xie; M. D. Gaca
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability

Psychopharmacology, 2017

Authors: M. F. Stiles; L. R. Campbell; D. W. Graff; B. A. Jones; R. V. Fant; J. E. Henningfield
Product Type: Vapour Products, Cigarettes
Study Type: Clinical Studies

Phase Ratio and Equilibrium Constant in RP-HPLC Obtained from Octanol/Water Partition Constant Through Solvophobic Theory

Chromatographia, 2017

Authors: S. C. Moldoveanu; E. Caiali; V. David
Study Type: Chemistry

Reduced biological effect of e-cigarette aerosol compared to cigarette smoke evaluated in vitro using normalized nicotine dose and RNA-seq-based toxicogenomics

Scientific Reports, 2017

Authors: L. E. Haswell; A. Baxter; A. Banerjee; I. Verrastro; J. Mushonganono; J. Adamson; D. Thorne; M. Gaca; E. Minet
Product Type: Vapour Products
Study Type: Toxicology

Role of Oxidative Stress in the Suppression of Immune Responses in Peripheral Blood Mononuclear Cells Exposed to Combustible Tobacco Product Preparation

Inflammation, 2017

Authors: S. Arimilli; E. Schmidt; B. E. Damratoski; G. L. Prasad
Product Type: Cigarettes
Study Type: Preclinical / In Vitro Disease Assessment

Stroke risk among menthol versus non-menthol cigarette smokers in the United States: Analysis of the National Health and Nutrition Examination Survey (NHANES)

Regulatory Toxicology and Pharmacology, 2017

Authors: C. Van Landingham; W. Fuller; G. Mariano; K. Marano; G. Curtin; S. I. Sulsky
Product Type: Cigarettes
Study Type: Consumer Use Behaviour, Preclinical/In Vitro Disease Assessment

The Adverse Outcome Pathway for Oxidative Stress-Mediated EGFR Activation Leading to Decreased Lung Function

Applied In Vitro Toxicology, 2017

Authors: K. Luettich; M. Talikka; F. J. Lowe; L. E. Haswell; J. Park; M. D. Gaca; J. Hoeng
Study Type: Preclinical / In Vitro Disease Assessment

The comparative in vitro assessment of e-cigarette and cigarette smoke aerosols using the gamma H2AX assay and applied dose measurements

Toxicology Letters, 2017

Authors: D. Thorne; S. Larard; A. Baxter; C. Meredith; M. Gaca
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

The determination of diacetyl and acetylpropionyl in aerosols from electronic smoking devices using gas chromatography triple quad mass spectrometry

Contributions to Tobacco & Nicotine Research, 2017

Authors: S. C. Moldoveanu; A. G. Hudson; A. Harrison
Product Type: Vapour Products
Study Type: Chemistry

Thermal desorption comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry for Vapour Products phase mainstream tobacco smoke analysis

Journal of Chromatography A, 2017

Authors: B. Savareear; M. Brokl; C. Wright; J. F. Focant
Product Type: Cigarettes
Study Type: Chemistry

Twenty-First Century In Vitro Toxicology Testing Methods and the Assessment of e-Cigarettes

Applied In Vitro Toxicology, 2017

Authors: J. R. Fowle; R. D. Curren; T. Hartung; C. Proctor; N. Wilcox
Product Type: Vapour Products
Study Type: Toxicology

A cross-sectional study of biomarkers of exposure and effect in smokers and moist snuff consumers

Clinical Chemistry and Laboratory Medicine, 2016

Authors: G. L. Prasad; B. A. Jones; P. Chen; E. O. Gregg
Product Type: Oral Tobacco Products
Study Type: Clinical Studies

AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos

Toxicology and Applied Pharmacology, 2016

Authors: A. Massarsky; A. J. Bone; W. Dong; D. E. Hinton; G. L. Prasad; R. T. Di Giulio
Study Type: Toxicology

Analysis of four pentacyclic triterpenoid acids in several bioactive botanicals with gas and liquid chromatography and mass spectrometry detection

Journal of Separation Science, 2016

Authors: S. C. Moldoveanu; W. A. Scott
Study Type: Chemistry

Application of dosimetry tools for the assessment of e-cigarette aerosol and cigarette smoke generated on two different in vitro exposure systems

Chemistry Central Journal, 2016

Authors: J. Adamson; D. Thorne; B. Zainuddin; A. Baxter; J. McAughey; M. Gaca
Product Type: Vapour Products
Study Type: Toxicology

Assessment of In Vitro COPD Models for Tobacco Regulatory Science: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use

Atla-Alternatives to Laboratory Animals, 2016

Authors: H. Behrsing; H. Raabe; J. Manuppello; B. Bombick; R. Curren; K. Sullivan; S. Sethi; R. Phipps; Y. Tesfaigzi; S. Yan; C. D'Ruiz; R. Tarran; S. Constant; G. Phillips; M. Gaca; P. Hayden; X. F. Cao; C. Mathis; J. Hoeng; A. Braun; E. Hill
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Assessment of key features of lignin from lignocellulosic crops: Stalks and roots of corn, cotton, sugarcane, and tobacco

Industrial Crops and Products, 2016

Authors: C. A. E. Costa; W. Coleman; M. Dube; A. E. Rodrigues; P. C. R. Pinto
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Chemical Composition of Aerosol from an E-Cigarette: A Quantitative Comparison with Cigarette Smoke

Chemical Research in Toxicology, 2016

Authors: J. Margham; K. McAdam; M. Forster; C. Liu; C. Wright; D. Mariner; C. Proctor
Product Type: Vapour Products
Study Type: Chemistry

Cigarette smoke induced genotoxicity and respiratory tract pathology: evidence to support reduced exposure time and animal numbers in tobacco product testing

Inhalation Toxicology, 2016

Authors: A. Dalrymple; P. Ordonez; D. Thorne; D. Walker; O. M. Camacho; A. Buttner; D. Dillon; C. Meredith
Product Type: Cigarettes
Study Type: Toxicology

Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls

Toxicological Sciences, 2016

Authors: S. T. Szabo; G. L. Harry; K. M. Hayden; D. T. Szabo; L. Birnbaum
Study Type: Preclinical / In Vitro Disease Assessment

Compatibilization of co-plasticized cellulose acetate/water soluble polymers blends by reactive extrusion

Polymer Degradation and Stability, 2016

Authors: R. Quintana; O. Persenaire; Y. Lemmouchi; L. Bonnaud; P. Dubois

Complementary HPLC-ICP-MS and synchrotron X-ray absorption spectroscopy for speciation analysis of chromium in tobacco samples

Journal of Analytical Atomic Spectrometry, 2016

Authors: S. Cuello; J. Entwisle; J. Benning; C. Liu; S. Coburn; K. G. McAdam; J. Braybrook; H. Goenaga-Infante
Product Type: Cigarettes
Study Type: Chemistry

Development, validation and application of a device to measure e-cigarette users' puffing topography

Scientific Reports, 2016

Authors: A. Cunningham; S. Slayford; C. Vas; J. Gee; S. Costigan; K. Prasad
Product Type: Vapour Products
Study Type: Consumer Use Behaviour

E-cigarette aerosols induce lower oxidative stress in vitro when compared to tobacco smoke

Toxicology mechanisms and methods, 2016

Authors: M. Taylor; T. Carr; O. Oke; T. Jaunky; D. Breheny; F. Lowe; M. Gaca
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Electronic cigarette aerosol induces significantly less cytotoxicity than tobacco smoke

Toxicology mechanisms and methods, 2016

Authors: D. Azzopardi; K. Patel; T. Jaunky; S. Santopietro; O. M. Camacho; J. McAughey; M. Gaca
Product Type: Vapour Products
Study Type: Toxicology

Evaluation of the phase ratio for three C18 high performance liquid chromatographic columns

Journal of Chromatography A, 2016

Authors: E. Caiali; V. David; H. Y. Aboul-Enein; S. C. Moldoveanu
Study Type: Chemistry

Influence of cigarette circumference on smoke chemistry, biological activity, and smoking behaviour

Regulatory Toxicology and Pharmacology, 2016

Authors: K. McAdam; A. Eldridge; I. M. Fearon; C. Liu; A. Manson; J. Murphy; A. Porter
Product Type: Cigarettes
Study Type: Chemistry, Toxicology, Consumer Use Behaviour

Influence of Type and Amount of Carbon in Cigarette Filters on Smokers' Mouth Level Exposure to Tar, Nicotine, 1,3-Butadiene, Benzene, Toluene, Isoprene, and Acrylonitrile

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2016

Authors: K. Nother; M. S. Ashley; P. M. Clayton
Product Type: Cigarettes
Study Type: Chemistry, Consumer Use Behaviour

Laccase oxidation and removal of toxicants released during combustion processes

Chemosphere, 2016

Authors: E. N. Prasetyo; S. Semlitsch; G. S. Nyanhongo; Y. Lemmouchi; G. M. Guebitz
Product Type: Cigarettes
Study Type: Chemistry

Multiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers

Bioanalysis, 2016

Authors: M. R. Kaluarachchi; C. L. Boulange; I. Garcia-Perez; J. C. Lindon; E. F. Minet
Product Type: Cigarettes
Study Type: Toxicology

Nicotine Analysis in Several Non-Tobacco Plant Materials

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2016

Authors: S. C. Moldoveanu; W. A. Scott; D. M. Lawson
Product Type: Nicotine
Study Type: Chemistry

Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling

Inhalation Toxicology, 2016

Authors: J. Campbell; A. Franzen; C. Van Landingham; M. Lumpkin; S. Crowell; C. Meredith; A. Loccisano; R. Gentry; H. Clewell
Study Type: Toxicology

Rapid detection of toxic compounds in tobacco smoke condensates using high-resolution H-1-nuclear magnetic resonance spectroscopy

Analytical Methods, 2016

Authors: J. Ticha; C. Wright
Product Type: Cigarettes
Study Type: Chemistry

Simulation of aerosol dynamics and deposition of combustible and electronic cigarette aerosols in the human respiratory tract

Journal of Aerosol Science, 2016

Authors: L. Pichelstorfer; W. Hofmann; R. Winkler-Heil; C. U. Yurteri; J. McAughey
Product Type: Vapour Products
Study Type: Aerosol Physics

The Activity and Enthalpy of Vaporization of Nicotine from Tobacco at Moderate Temperatures

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2016

Authors: F. K. St Charles; S. C. Moldoveanu
Product Type: Cigarettes
Study Type: Chemistry

The mutagenic assessment of an electronic-cigarette and reference cigarette smoke using the Ames assay in strains TA98 and TA100

Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2016

Authors: D. Thorne; I. Crooks; M. Hollings; A. Seymour; C. Meredith; M. Gaca
Product Type: Vapour Products, Cigarettes
Study Type: Toxicology

Thermal behaviour of selected flavour ingredients and additives under simulated cigarette combustion and tobacco heating conditions

Journal of Analytical and Applied Pyrolysis, 2016

Authors: Z. Czégény; J. Bozi; Z. Sebestyén; M. Blazsó; E. Jakab; E. Barta-Rajnai; M. Forster; J. Nicol; K. G. McAdam; C. Liu
Product Type: Heated Products, Cigarettes
Study Type: Aerosol Physics, Chemistry

Thermodynamic and kinetic behavior of glycerol aerosol

Aerosol Science and Technology, 2016

Authors: T. P. Wright; C. Song; S. Sears; M. D. Petters
Product Type: Vapour Products
Study Type: Aerosol Physics

Water-dispersive PLA-based materials: from reactive melt processing to properties

Polymers for Advanced Technologies, 2016

Authors: O. Persenaire; R. Q. Vincente; L. Bonnaud; Y. Lemmouchi; P. Dubois
Study Type: Chemistry

A comparative assessment of cigarette smoke aerosols using an in vitro air-liquid interface cytotoxicity test

Inhalation Toxicology, 2015

Authors: D. Thorne; A. Dalrymple; D. Dillon; M. Duke; C. Meredith
Product Type: Cigarettes
Study Type: Toxicology

A longitudinal study of smokers' exposure to cigarette smoke and the effects of spontaneous product switching

Regulatory Toxicology and Pharmacology, 2015

Authors: A. Cunningham; J. Sommarstrom; O. M. Camacho; A. S. Sisodiya; K. Prasad
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites

Chemico-Biological Interactions, 2015

Authors: J. Campbell; C. Van Landingham; S. Crowell; R. Gentry; D. Kaden; S. Fiebelkorn; A. Loccisano; H. Clewell
Study Type: Toxicology

A validated method to measure benzo[a]pyrene concentrations in tobacco by high-performance liquid chromatography-fluorescence detection

Analytical Methods, 2015

Authors: M. Carradus; K. G. McAdam; J. D. H. van Heemst; C. H. A. Goss; C. Wright
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Chemistry

An approach to ingredient screening and toxicological risk assessment of flavours in e-liquids

Regulatory Toxicology and Pharmacology, 2015

Authors: S. Costigan; C. Meredith
Product Type: Vapour Products
Study Type: Toxicology

An experimental method to study emissions from heated tobacco between 100-200 degrees C

Chemistry Central Journal, 2015

Authors: M. Forster; C. Liu; M. G. Duke; K. G. McAdam; C. J. Proctor
Product Type: Heated Products
Study Type: Chemistry

An improved method for the isolation of rat alveolar type II lung cells: Use in the Comet assay to determine DNA damage induced by cigarette smoke

Regulatory Toxicology and Pharmacology, 2015

Authors: A. Dalrymple; P. Ordonez; D. Thorne; D. Dillon; C. Meredith
Product Type: Cigarettes
Study Type: Toxicology

Analysis of hydrazine in smokeless tobacco products by gas chromatography-mass spectrometry

Chemistry Central Journal, 2015

Authors: K. McAdam; H. Kimpton; S. Essen; P. Davis; C. Vas; C. Wright; A. Porter; B. Rodu
Product Type: Oral Tobacco Products
Study Type: Chemistry

Analysis of small carbohydrates in several bioactive botanicals by gas chromatography with mass spectrometry and liquid chromatography with tandem mass spectrometry

Journal of Separation Science, 2015

Authors: S. Moldoveanu; W. Scott; J. Zhu
Study Type: Chemistry

Changes in Biomarkers of Exposure and Subjective Effects When Smokers Switch to Dual Use of Cigarettes and Either Snus or a Dissolvable Tobacco Product: A Summary of Three Clinical Studies

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2015

Authors: E. K. Round; L. R. Campbell; M. F. Stiles; M. Dixon; M. F. Borgerding
Product Type: Oral Tobacco Products
Study Type: Consumer Use Behaviour, Clinical Studies

Changes in levels of biomarkers of exposure and biological effect in a controlled study of smokers switched from conventional cigarettes to reduced-toxicant-prototype cigarettes

Regulatory Toxicology and Pharmacology, 2015

Authors: C. J. Shepperd; N. Newland; A. Eldridge; L. Haswell; F. Lowe; E. Papadopoulou; O. Camacho; C. J. Proctor; D. Graff; I. Meyer
Product Type: Cigarettes
Study Type: Clinical Studies

Consumption patterns and biomarkers of exposure in cigarette smokers switched to Snus, various dissolvable tobacco products, Dual use, or tobacco abstinence

Regulatory Toxicology and Pharmacology, 2015

Authors: G. R. Krautter; P. X. Chen; M. F. Borgerding
Product Type: Oral Tobacco Products
Study Type: Consumer Use Behaviour, Clinical Studies

Development and Characterisation of a Smoking Behaviour Measurement System

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2015

Authors: C. A Vas; C. U. Yurteri; C.J.Dickens; K. Prasad
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Development of an in vitro cytotoxicity model for aerosol exposure using 3D reconstructed human airway tissue; application for assessment of e-cigarette aerosol

Toxicology in Vitro, 2015

Authors: L. Neilson; C. Mankus; D. Thorne; G. Jackson; J. Debay; C. Meredith
Product Type: Vapour Products
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

Clinical Chemistry and Laboratory Medicine, 2015

Authors: C. Andreoli; A. Bassi; E. O. Gregg; A. Nunziata; R. Puntoni; E. Corsini
Product Type: Cigarettes
Study Type: Clinical Studies, Preclinical/In Vitro Disease Assessment

Empirical characterisation of ranges of mainstream smoke toxicant yields from contemporary cigarette products using quantile regression methodology

Regulatory Toxicology and Pharmacology, 2015

Authors: O. M. Camacho; A. Eldridge; C. J. Proctor; K. McAdam
Product Type: Cigarettes
Study Type: Chemistry

Estimation of the phase ratio in reversed-phase high-performance liquid chromatography

Journal of Chromatography A, 2015

Authors: S. Moldoveanu; V. David
Study Type: Chemistry

Evaluation of an air-liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols

Toxicology in Vitro, 2015

Authors: D. Azzopardi; L. E. Haswell; G. Foss-Smith; K. Hewitt; N. Asquith; S. Corke; G. Phillips
Product Type: Cigarettes
Study Type: Toxicology

Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States

Health and Quality of Life Outcomes, 2015

Authors: J. E. Ware; B. Gandek; A. Kulasekaran; R. Guyer
Study Type: Consumer Use Behaviour, Population Health Impact

Evaluation of the Content of Free Amino Acids in Tobacco by a New Liquid Chromatography-Tandem Mass Spectrometry Technique

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2015

Authors: S. C. Moldoveanu; J. Zhu; Scott, A. Wayne
Product Type: Tobacco
Study Type: Chemistry

Examination of the use of human sera as an exposure agent for in vitro studies investigating the effects of cigarette smoking on cellular cardiovascular disease models

Toxicology in Vitro, 2015

Authors: K. McQuillan; T. Carr; M. Taylor; E. Bishop; I. M. Fearon
Product Type: Cigarettes
Study Type: Toxicology, Preclinical/In Vitro Disease Assessment

Free amino acids analysis by liquid chromatography with tandem mass spectrometry in several botanicals with antioxidant character

Journal of Separation Science, 2015

Authors: S. C. Moldoveanu; J. Zhu; N. Qian
Study Type: Chemistry

Highly Time-Resolved Imaging of Combustion and Pyrolysis Product Concentrations in Solid Fuel Combustion: NO Formation in a Burning Cigarette

Analytical Chemistry, 2015

Authors: R. Zimmermann; R. Hertz-Schunemann; S. Ehlert; C. Liu; K. McAdam; R. Baker; T. Streibel
Product Type: Cigarettes
Study Type: Chemistry

High-resolution time and spatial imaging of tobacco and its pyrolysis products during a cigarette puff by microprobe sampling photoionisation mass spectrometry

Analytical and Bioanalytical Chemistry, 2015

Authors: R. Hertz-Schunemann; S. Ehlert; T. Streibel; C. Liu; K. McAdam; R. R. Baker; R. Zimmermann
Product Type: Cigarettes
Study Type: Chemistry

Hygroscopic effects on the mobility and mass of cigarette smoke particles

Journal of Aerosol Science, 2015

Authors: T. J. Johnson; J. S. Olfert; C. U. Yurteri; R. Cabot; J. McAughey
Product Type: Cigarettes
Study Type: Aerosol Physics

Laccase functionalized cellulose acetate for the removal of toxic combustion products

Reactive & Functional Polymers, 2015

Authors: E. N. Prasetyo; S. Semlitsch; G. S. Nyanhongo; Y. Lemmouchi; G. M. Guebitz
Product Type: Cigarettes
Study Type: Chemistry

Magnitudes of biomarker reductions in response to controlled reductions in cigarettes smoked per day: A one-week clinical confinement study

Regulatory Toxicology and Pharmacology, 2015

Authors: E. H. Theophilus; C. R. E. Coggins; P. Chen; E. Schmidt; M. F. Borgerding
Product Type: Cigarettes
Study Type: Clinical Studies

Nitrate metabolism in tobacco leaves overexpressing Arabidopsis nitrite reductase

Plant Physiology and Biochemistry, 2015

Authors: S. Davenport; P. Le Lay; J. P. Sanchez-Tamburrrino
Study Type: Agronomy/Plant Biotechnology

Particle size distribution of e-cigarette aerosols and the relationship to Cambridge filter pad collection efficiency

Contributions to Tobacco & Nicotine Research, 2015

Authors: S. L. Alderman; C. Song; S. C. Moldoveanu; S. K. Cole
Product Type: Vapour Products
Study Type: Aerosol Physics

Preliminary Evaluation of a New German Translated Tobacco Quality of Life Impact Tool to Discriminate Between Healthy Current and Former Smokers and to Explore the Effect of Switching Smokers to a Reduced Toxicant Prototype Cigarette

Nicotine & Tobacco Research, 2015

Authors: A. Kulasekaran; C. Proctor; E. Papadopoulou; C. J. Shepperd; R. Guyer; B. Gandek; J. E. Ware
Product Type: Cigarettes
Study Type: Clinical Studies

RNA-sequencing Reveals Global Transcriptomic Changes in Nicotiana tabacum Responding to Topping and Treatment of Axillary-shoot Control Chemicals

Scientific Reports, 2015

Authors: S. K. Singh; Y. M. Wu; J. S. Ghosh; S. Pattanaik; C. Fisher; Y. Wang; D. Lawson; L. Yuan
Product Type: Tobacco
Study Type: Agronomy/Plant Biotechnology

Standardized methods for the regulation of cigarette-smoke constituents

Trac-Trends in Analytical Chemistry, 2015

Authors: C. Wright
Study Type: Chemistry

Study of cardiovascular disease biomarkers among tobacco consumers, part 1: biomarkers of exposure

Inhalation Toxicology, 2015

Authors: L. R. Campbell; B. G. Brown; B. A. Jones; K. M. Marano; M. F. Borgerding
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Clinical Studies

Study of cardiovascular disease biomarkers among tobacco consumers, part 2: biomarkers of biological effect

Inhalation Toxicology, 2015

Authors: B. K. Nordskog; B. G. Brown; K. M. Marano; L. R. Campell; B. A. Jones; M. F. Borgerding
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Clinical Studies

Study of cardiovascular disease biomarkers among tobacco consumers. Part 3: evaluation and comparison with the US National Health and Nutrition Examination Survey

Inhalation Toxicology, 2015

Authors: K. M. Marano; S. J. Kathman; B. A. Jones; B. K. Nordskog; B. G. Brown; M. F. Borgerding
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Clinical Studies

Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 1. Study design and methodology

Biomarkers, 2015

Authors: M. W. Ogden; K. M. Marano; B. A. Jones; M. F. Stiles
Product Type: Oral Tobacco Products, Heated Products, Cigarettes
Study Type: Clinical Studies

Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 2. Biomarkers of exposure

Biomarkers, 2015

Authors: M. W. Ogden; K. M. Marano; B. A. Jones; W. T. Morgan; M. F. Stiles
Product Type: Oral Tobacco Products, Heated Products, Cigarettes
Study Type: Clinical Studies

Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 3. Biomarkers of biological effect

Biomarkers, 2015

Authors: M. W. Ogden; K. M. Marano; B. A. Jones; W. T. Morgan; M. F. Stiles
Product Type: Cigarettes
Study Type: Clinical Studies

Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine

Neurotoxicology and Teratology, 2015

Authors: A. Massarsky; N. Jayasundara; J. M. Bailey; A. N. Oliveri; E. D. Levin; G. L. Prasad; R. T. Di Giulio
Product Type: Cigarettes
Study Type: Toxicology

The acrylamide content of smokeless tobacco products

Chemistry Central Journal, 2015

Authors: K. McAdam; H. Kimpton; C. Vas; D. Rushforth; A. Porter; B. Rodu
Product Type: Oral Tobacco Products
Study Type: Chemistry

The combination of two novel tobacco blends and filter technologies to reduce the in vitro genotoxicity and cytotoxicity of prototype cigarettes

Regulatory Toxicology and Pharmacology, 2015

Authors: I. Crooks; K. Scott; A. Dalrymple; D. Dillon; C. Meredith
Product Type: Cigarettes
Study Type: Toxicology

The mutagenic assessment of mainstream cigarette smoke using the Ames assay: A multi-strain approach

Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2015

Authors: D. Thorne; J. Kilford; M. Hollings; A. Dalrymple; M. Ballantyne; C. Meredith; D. Dillon
Product Type: Cigarettes
Study Type: Toxicology

Toxicological evaluation of smokeless tobacco: 2-year chronic toxicity and carcinogenicity feeding study in Wistar Han rats

Experimental and Toxicologic Pathology, 2015

Authors: E. H. Theophilus; J. R. Hayes; P. H. Ayres; W. T. Morgan; R. J. Potts; C. D. Garner; D. M. Fallacara; M. R. Hejtmancik; A. W. Singer
Product Type: Oral Tobacco Products
Study Type: Toxicology

Transient measurement of the effective particle density of cigarette smoke

Journal of Aerosol Science, 2015

Authors: T. J. Johnson; J. S. Olfert; R. Cabot; C. Treacy; C. U. Yurteri; C. Dickens; J. McAughey; J. P. R. Symonds
Product Type: Cigarettes
Study Type: Aerosol Physics

Validation of Part-Filter Analysis to Estimate Smokers' Mouth Level Exposure to 'Tar' and Nicotine

Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 2015

Authors: K. Prasad; M. Ashley; M. Dixon
Product Type: Cigarettes
Study Type: Consumer Use Behaviour

Variation in tobacco and mainstream smoke toxicant yields from selected commercial cigarette products

Regulatory Toxicology and Pharmacology, 2015

Authors: A. Eldridge; T. R. Betson; M. V. Gama; K. McAdam
Product Type: Cigarettes
Study Type: Chemistry

Combusted but not smokeless tobacco products cause DNA damage in oral cavity cells

Environmental Toxicology and Pharmacology, 2014

Authors: H. Gao; G. L. Prasad; W. Zacharias
Product Type: Nicotine, Oral Tobacco Products, Cigarettes
Study Type: Toxicology

Comparison of Consumption Patterns, Biomarkers of Exposure, and Subjective Effects in Cigarette Smokers Who Switched to Dissolvable Tobacco (Camel Orbs), Dual Use, or Tobacco Abstinence

Nicotine & Tobacco Research, 2014

Authors: G. R. Krautter; M. F. Borgerding
Product Type: Oral Tobacco Products
Study Type: Clinical Studies

Regulation of gene expression by tobacco product preparations in cultured human dermal fibroblasts

Toxicology and Applied Pharmacology, 2014

Authors: G. E. Malpass; S. Arimilli; G. L. Prasad; A. C. Howlett
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology

Assessment of Mouth-Level Exposure to Tobacco Constituents in U.S. Snus Consumers

Nicotine & Tobacco Research, 2013

Authors: J. W. Caraway; P. X. Chen
Product Type: Oral Tobacco Products
Study Type: Consumer Use Behaviour

Combustible and non-combustible tobacco product preparations differentially regulate human peripheral blood mononuclear cell functions

Toxicology in Vitro, 2013

Authors: S. Arimilli; B. E. Damratoski; G. L. Prasad
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology

Determination of Nicotine Absorption from Multiple Tobacco Products and Nicotine Gum

Nicotine & Tobacco Research, 2013

Authors: H. Digard; C. Proctor; A. Kulasekaran; U. Malmqvist; A. Richter
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Clinical Studies

Differential cell-specific cytotoxic responses of oral cavity cells to tobacco preparations

Toxicology in Vitro, 2013

Authors: H. Gao; G. L. Prasad; W. Zacharias
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Toxicology

Multi-analyte approach for determining the extraction of tobacco constituents from pouched snus by consumers during use

Chemistry Central Journal, 2013

Authors: H. Digard; N. Gale; G. Errington; N. Peters; K. McAdam
Product Type: Oral Tobacco Products
Study Type: Chemistry

Polycyclic aromatic hydrocarbons in US and Swedish smokeless tobacco products

Chemistry Central Journal, 2013

Authors: K. G. McAdam; A. Faizi; H. Kimpton; A. Porter; B. Rodu
Product Type: Oral Tobacco Products
Study Type: Chemistry

Survey of GPs' understanding of tobacco and nicotine products

Drugs and Alcohol Today, 2013

Authors: S. R. Patwardhan; M. A. Murphy
Product Type: Nicotine, Oral Tobacco Products, Vapour Products, Cigarettes
Study Type: Population Health Impact

Electronic cigarette aerosol particle size distribution measurements

Inhalation Toxicology, 2012

Authors: B. J. Ingebrethsen; S. K. Cole; S. L. Alderman
Product Type: Vapour Products
Study Type: Aerosol Physics

The chemical composition of smokeless tobacco: A survey of products sold in the United States in 2006 and 2007

Regulatory Toxicology and Pharmacology, 2012

Authors: M. F. Borgerding; J. A. Bodnar; G. M. Curtin; J. E. Swauger
Product Type: Oral Tobacco Products
Study Type: Chemistry

Toxicological evaluation of smokeless tobacco: 90-Day rodent feeding studies

Experimental and Toxicologic Pathology, 2012

Authors: E. H. Theophilus; J. R. Hayes; R. J. Potts; P. H. Ayres; C. D. Williams; C. D. Garner
Product Type: Oral Tobacco Products
Study Type: Toxicology

Acrylamide Analysis in Tobacco, Alternative Tobacco Products, and Cigarette Smoke

Journal of Chromatographic Science, 2011

Authors: S. C. Moldoveanu; A. R. Gerardi
Product Type: Oral Nicotine Products, Oral Tobacco Products, Cigarettes
Study Type: Chemistry

Differential exposure biomarker levels among cigarette smokers and smokeless tobacco consumers in the National Health and Nutrition Examination Survey 1999-2008

Biomarkers, 2011

Authors: Z. S. Naufal; K. M. Marano; S. J. Kathman; C. L. Wilson
Product Type: Oral Tobacco Products, Cigarettes
Study Type: Clinical Studies

Patterns and behaviors of snus consumption in Sweden

Nicotine & Tobacco Research, 2009

Authors: H. Digard; G. Errington; A. Richter; K. McAdam
Product Type: Oral Tobacco Products
Study Type: Consumer Use Behaviour

The potential role of snus products within a tobacco harm reduction strategy

Journal of Public Health, 2009

Authors: S. Patwardhan
Product Type: Oral Tobacco Products

Should the health community promote smokeless tobacco (snus): Comments from British American Tobacco

PLOS Medicine, 2007

Authors: J. Williamson; C. Proctor
Product Type: Oral Tobacco Products

A comparison of in vitro toxicities of cigarette smoke condensate from Eclipse cigarettes and four commercially available ultra low-"tar" cigarettes

Food and Chemical Toxicology, 2004

Authors: J. W. D. Foy; B. R. Bombick; D. W. Bombick; D. J. Doolittle; A. T. Mosberg; J. E. Swauger
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Comparative study of smoke condensates from 1R4F cigarettes that burn tobacco versus ECLIPSE cigarettes that primarily heat tobacco in the SENCAR mouse dermal tumor promotion assay

Food and Chemical Toxicology, 2004

Authors: D. R. Meckley; J. R. Hayes; K. R. Van Kampen; P. H. Ayres; A. T. Mosberg; J. E. Swauger
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Eclipse: Does it live up to its health claims?

Tobacco Control, 2003

Authors: J. E. Swauger; G. N. Connolly
Product Type: Heated Products

Quantification of continuous glass filaments on eclipse cigarettes retrieved from the test market

Inhalation Toxicology, 2003

Authors: M. A. Higuchi; P. H. Ayres; J. E. Swauger; P. A. Deal; T. Guy; M. Morton; A. T. Mosberg
Product Type: Heated Products

Relationship between FTC 'tar' and urine mutagenicity in smokers of tobacco-burning or Eclipse cigarettes

Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2002

Authors: D. L. Bowman; C. J. Smith; B. R. Bombick; J. T. Avalos; R. A. Davis; W. T. Morgan; D. J. Doolittle
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Subchronic inhalation by rats of mainstream smoke from a cigarette that primarily heats tobacco compared to a cigarette that burns tobacco

Inhalation Toxicology, 2001

Authors: D. L. Bowman; C. J. Smith; B. R. Bombick; J. T. Avalos; R. A. Davis; W. T. Morgan; D. J. Doolittle
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

The role of glutathione in the toxicity of smoke condensates from cigarettes that burn or heat tobacco

Free Radical Biology and Medicine, 2001

Authors: C. A. Waldren; D. B. Vannais; M. S. Knowlton; K. K. Domenico; C. J. Smith; D. J. Doolitttle
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Analysis of potential transfer of continuous glass filament from eclipse cigarettes

Inhalation Toxicology, 2000

Authors: M. A. Higuchi; P. H. Ayres; J. E. Swauger; W. T. Morgan; A. T. Mosberg
Product Type: Heated Products

Cap junction intercellular communication and cytotoxicity in normal human cells after exposure to smoke condensates from cigarettes that burn or primarily heat tobacco

Toxicology in Vitro, 2000

Authors: S. C. McKarns; D. W. Bombick; M. J. Morton; D. J. Doolittle
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Health consequences of eclipse cigarette

Journal of the American Medical Association, 2000

Authors: G. T. Burger; J. E. Swauger; M. J. Thun; T. J. Glynn
Product Type: Heated Products

Quantitative analysis of potential transfer of continuous glass filament from eclipse prototype 9-014 cigarettes

Inhalation Toxicology, 2000

Authors: M. A. Higuchi; P. H. Ayres; J. E. Swauger; W. T. Morgan; A. T. Mosberg
Product Type: Heated Products

Safety assessment of continuous glass filaments used in eclipse

Inhalation Toxicology, 2000

Authors: J. E. Swauger; J. W. D. Foy
Product Type: Heated Products
Study Type: Toxicology

Re: Safe cigarette alternatives? Industry critics say 'not yet'

Journal of the National Cancer Institute, 1999

Authors: J. E. Swauger
Product Type: Heated Products

Comparative studies of DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or primarily heat tobacco

Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 1998

Authors: B. Brown; J. Kolesar; K. Lindberg; D. Meckley; A. Mosberg; D. Doolittle
Product Type: Heated Products
Study Type: Toxicology

Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 2. In vitro toxicology of mainstream smoke condensate

Food and Chemical Toxicology, 1998

Authors: B. R. Bombick; H. Murli; J. T. Avalos; D. W. Bombick; W. T. Morgan; K. P. Putnam; D. J. Doolittle
Product Type: Heated Products
Study Type: Toxicology

Comparative studies of the mutagenicity of environmental tobacco smoke from cigarettes that burn or primarily heat tobacco

Environmental and Molecular Mutagenesis, 1998

Authors: B. R. Bombick; J. T. Avalos; P. R. Nelson; F. W. Conrad; D. J. Doolittle
Product Type: Heated Products
Study Type: Toxicology

Comparative cytotoxicity studies of smoke condensates from different types of cigarettes and tobaccos

Toxicology in Vitro, 1998

Authors: D. W. Bombick; K. Putnam; D. J. Doolittle
Product Type: Heated Products
Study Type: Toxicology

Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 3. In vitro toxicity of whole smoke

Food and Chemical Toxicology, 1998

Authors: D. W. Bombick; P. H. Ayres; K. Putnam; B. R. Bombick; D. J. Doolittle
Product Type: Heated Products
Study Type: Toxicology

Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 1. Chemical composition of mainstream smoke

Food and Chemical Toxicology, 1998

Authors: M. F. Borgerding; J. A. Bodnar; H. L. Chung; P. P. Mangan; C. C. Morrison; C. H. Risner; J. C. Rogers; D. F. Simmons; M. S. Uhrig; F. N. Wendelboe; D. E. Wingate; L. S. Winkler
Product Type: Heated Products
Study Type: Chemistry

Studies of environmental tobacco smoke generated by different cigarettes

Journal of the Air & Waste Management Association, 1998

Authors: P. R. Nelson; S. P. Kelly; F. W. Conrad
Product Type: Heated Products, Cigarettes
Study Type: Chemistry, Consumer Impact Science

Comparative study of DNA adduct formation in mice following inhalation of smoke from cigarettes that burn or primarily heat tobacco

Environmental and Molecular Mutagenesis, 1997

Authors: B. G. Brown; C. K. Lee; B. R. Bombick; P. H. Ayres; A. T. Mosberg; D. J. Doolittle
Product Type: Heated Products
Study Type: Toxicology

Human urine mutagenicity study comparing cigarettes which burn or primarily heat tobacco

Mutation Research-Environmental Mutagenesis and Related Subjects, 1996

Authors: C. J. Smith; S. C. McKarns; R. A. Davis; S. D. Livingston; B. R. Bombick; J. T. Avalos; W. T. Morgan; D. J. Doolittle
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Sensory Responses To Environmental Tobacco Smoke From Tobacco?Burning And Tobacco?Heating Cigarettes

Indoor Air, 1993

Authors: J. C. Walker; R. A. Jennings; P. R. Nelson; W. T. Morgan; D. L. Heavner; J. H. Robinson; J. D. DeBethizy; M. W. Stancill
Product Type: Heated Products, Cigarettes
Study Type: Clinical Studies

2-week and 13-week inhalation studies of aerosolized glycerol in rats

Inhalation Toxicology, 1992

Authors: R. A. Renne; A. P. Wehner; B. J. Greenspan; H. S. Deford; H. A. Ragan; R. B. Westerberg; R. L. Buschbom; G. T. Burger; A. W. Hayes; R. L. Suber; A. T. Mosberg
Study Type: Toxicology

DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or heat tobacco

Environmental and Molecular Mutagenesis, 1992

Authors: C. K. Lee; B. G. Brown; E. A. Reed; M. Hejtmancik; A. T. Mosberg; D. J. Doolittle; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

A quantitative approach to assessing intercellular communication: Studies on cigarette smoke condensates

Toxicology and Applied Pharmacology, 1991

Authors: S. C. McKarns; D. J. Doolittle
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Correlations between urinary nicotine or cotinine and urinary mutagenicity in smokers on controlled diets

Environmental and Molecular Mutagenesis, 1991

Authors: C. A. Rahn; G. Howard; E. Riccio; D. J. Doolittle
Product Type: Heated Products, Cigarettes
Study Type: Toxicology, Clinical Studies

The Determination of Benzo[a]Pyrene and Benz[a]Anthracene in Mainstream and Sidestream Smoke of the Kentucky Reference Cigarette 1R4F and a Cigarette Which Heats but Does Not Burn Tobacco: A Comparison

Beitrage Zur Tabakforschung International, 1991

Authors: C. H. Risner
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

A comparison of the free radical chemistry of tobacco-burning cigarettes and cigarettes that only heat tobacco

Free Radical Biology and Medicine, 1990

Authors: W. A. Pryor; D. F. Church; M. D. Evans; W. Y. Rice; J. R. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

A High-Performance Liquid Chromatographic Determination of Major Phenolic Compounds in Tobacco Smoke

Journal of Chromatographic Science, 1990

Authors: C. H. Risner; S. L. Cash
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Analysis of cytogenetic effects in bone-marrow cells of rats subchronically exposed to smoke from cigarettes which burn or only heat tobacco

Mutation Research, 1990

Authors: C. K. Lee; B. G. Brown; E. A. Reed; G. D. Lowe; S. C. McKarns; C. W. Fulp; C. R. E. Coggins; P. H. Ayres; D. J. Doolittle
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Artifact formation during smoke trapping: an improved method for determination of N-nitrosamines in cigarette smoke

Journal of the Association of Official Analytical Chemists, 1990

Authors: W. S. Caldwell; J. M. Conner
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Chemical and biological studies of a cigarette that heats rather than burns tobacco

Journal of Clinical Pharmacology, 1990

Authors: J. D. Debethizy; M. F. Borgerding; D. J. Doolittle; J. H. Robinson; K. T. McManus; C. A. Rahn; R. A. Davis; G. T. Burger; J. R. Hayes; J. H. Reynolds; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Chemistry, Toxicology, Clinical Studies

Cigarette smoke composition. Part 1. Limitations of FTC method when applied to cigarettes that heat instead of burn tobacco

Journal of the Association of Official Analytical Chemists, 1990

Authors: M. F. Borgerding; R. D. Hicks; J. E. Bodnar; D. M. Riggs; E. J. Nanni; G. W. Fulp; W. C. Hamlin; J. A. Giles
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Cigarette smoke composition. Part 2. Method for determining major components in smoke of cigarettes that heat instead of burn tobacco.

Journal of the Association of Official Analytical Chemists, 1990

Authors: M. F. Borgerding; L. A. Milhous; R. D. Hicks; J. A. Giles
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Comparative genotoxicity testing of mainstream whole smoke from cigarettes which burn or heat tobacco

Mutation Research, 1990

Authors: C. K. Lee; D. J. Doolittle; G. T. Burger; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco

Environmental and Molecular Mutagenesis, 1990

Authors: D. J. Doolittle; C. K. Lee; J. L. Ivett; J. C. Mirsalis; E. Riccio; C. J. Rudd; G. T. Burger; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Comparative subchronic inhalation bioassay in hamsters of a cicarette that only heats tobacco

Inhalation Toxicology, 1990

Authors: A. P. Wehner; R. A. Renne; B. J. Greenspan; H. S. Deford; H. A. Ragan; R. B. Mterberg; C. W. Wright; R. L. Buschbom; G. T. Burger; A. W. Hayes; C. R. E. Coggins; A. T. Mosberg
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Genetic toxicology studies comparing the activity of sidestream smoke from cigarettes which burn or only heat tobacco

Mutation Research, 1990

Authors: D. J. Doolittle; C. K. Lee; J. L. Ivett; J. C. Mirsalis; E. Riccio; C. J. Rudd; G. T. Burger; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Histopathology, urine mutacenicity, and bone marrow cytocenetics of mice exposed nose-only to smoke from cigarettes that burn or heat tobacco

Inhalation Toxicology, 1990

Authors: C. R. E. Coggins; D. L. Doolittle; C. K. Lee; Ph. H. Ayres; A. T. Mosberg; D. C. Bolin; G. T. Burger; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Isotope dilution gas chromatography-mass spectrometry in the determination of benzene, toluene, styrene and acrylonitrile in mainstream cigarette smoke

Journal of Chromatography, 1990

Authors: G. D. Byrd; K. W. Fowler; R. D. Hicks; M. E. Lovette; M. F. Borgerding
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Separation and Quantitation of Monovalent Anionic and Cationic Species in Mainstream Cigarette Smoke Aerosols by High-Performance Ion Chromatography

Journal of Chromatographic Science, 1990

Authors: E. J. Nanni; M. E. Lovette; R. D. Hicks; K. W. Fowler; M. F. Borgerding
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Separation and quantitation of phenolic compounds in mainstream cigarette smoke by capillary gas chromatography with mass spectrometry in the selected-ion mode

Journal of Chromatography, 1990

Authors: E. J. Nanni; M. E. Lovette; R. D. Hicks; K. W. Fowler; M. F. Borgerding
Product Type: Heated Products, Cigarettes
Study Type: Chemistry

Comparative inhalation study in rats, using a second prototype of a cigarette that heats rather than burns tobacco

Inhalation Toxicology, 1989

Authors: C. R. E. Coggins; P. H. Ayres; A. T. Mosberg; G. T. Burger; J. W. Sagartz; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Human urine mutagenicity study comparing cigarettes which burn or only heat tobacco

Mutation Research, 1989

Authors: D. J. Doolittle; C. A. Rahn; G. T. Burger; R. Davis; J. D. Debethizy; G. Howard; C. K. Lee; S. C. McKarns; E. Riccio; J. Robinson; J. Reynolds; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Clinical Studies, Toxicology

Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that burn tobacco

Fundamental and Applied Toxicology, 1989

Authors: C. R. E. Coggins; P. H. Ayres; A. T. Mosberg; J. W. Sagartz; G. T. Burger; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Toxicology

Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats

Food and Chemical Toxicology, 1989

Authors: R. L. Suber; R. Deskin; I. Nikiforov; X. Fouillet; C. R. E. Coggins
Study Type: Toxicology

Absorption of nicotine from a cigarette that does not burn tobacco

Pharmacology, 1988

Authors: J. D. Debethizy; J. H. Robinson; R. A. Davis; D. J. Doolittle; G. T. Burger; J. H. Reynolds; R. G. Fletcher; A. W. Hayes
Product Type: Heated Products, Cigarettes
Study Type: Clinical Studies