The science behind

ePen 3

Mouthpiece

Battery

USB charging port

Casing

Activation button

  1. Mouthpiece
  2. Battery
  3. USB Charging port
  4. Casing
  5. Activation button

Vype ePen 3 is a closed vapour system.

This powerful device uses coil and wick technology to deliver vapour. It features click in and out pods that are pre-filled with flavoured e-liquid.

 

How we tested the Vype ePen 3

Let’s see how the ePen 3 performed when put to the test by our scientists.

Behavioural studies

Behavioural studies can help us understand how people use Vype. Puffing on a vapour product might seem simple but it involves a number of separate actions – all of which may affect what the consumer is exposed to. We have conducted 27 different kinds of studies to help us understand how consumers use this product.

Our results show that smokers and Vype consumers use their products in very different ways, and the behaviour of vapour consumers depends on the type of product they use.

These results inform how we programme our vaping robots in the lab, thereby ensuring that we produce Vype vapour in as realistic a way as possible for further analysis and studies. This means we can be confident in the results we get when we test the vapour.

 

Around 95%* reduced toxicants

Chemistry tests tell us what’s in the ePen 3 vapour. This is important because this is what a consumer is potentially exposed to when they use it. Vapour devices like the ePen 3 don’t contain tobacco and therefore should have less toxicants in their vapour than smoke.

We performed a series of chemical tests designed to look for specific compounds in the ePen 3 vapour, and we compared the results with what is in cigarette smoke.

Our results reveal the ePen 3 vapour to have fewer and lower levels of certain toxicants than cigarette smoke. Some toxicants found in smoke are not in the ePen 3 vapour at all and others are much reduced by around 95%.*

Our results confirm the simple composition of the ePen 3 vapour, compared to smoke. ePen 3 consumers should therefore be exposed to less toxicants than smokers.



*Comparison of smoke from a 1R6F reference cigarette and vapour from Vype ePen 3, in terms of the 9 harmful components the World Health Organization recommends to reduce in cigarette smoke. This quality does not mean this product is less harmful than tobacco products.

Low or no impact on human cells

Biological tests tell us what the ePen 3 vapour does to human cells in the lab and how that compares to what smoke does to cells. We already know from chemical testing that the ePen 3 vapour contains less harmful chemicals than smoke. In theory therefore, cells exposed to the ePen 3 vapour should experience less toxicity compared to smoke. We performed 35 tests to determine if this is the case.

We use living human cells in the lab as models for tissues and organs in the body and test the impact of the Vype vapour on these cells and compare it to the impact of cigarette smoke.

Cells exposed to smoke exhibit many responses relevant to disease development, whereas those cells exposed to ePen 3 either exhibit much lower responses or no response at all*.

This quality does not necessarily mean this product is less harmful than tobacco products, but may add to growing evidence that ePen 3 has the potential to be reduced risk compared to conventional cigarettes.


*Comparison of smoke from a 1R6F reference cigarette and vapour from Vype ePen 3, in terms of mutagenicity, genotoxicity, cytotoxicity and tumour-promoting potential.
 

Clinical tests

We have conducted 20 clinical tests to help us understand the impact Vype can have on the human body.

Clinical tests involve real consumers – often hundreds in one study alone. These consumers are monitored over a set period of time whilst using our products, and we collect readings for certain chemicals in urine, blood, saliva and breath samples. These readings can then be compared to the readings for consumers in the study who smoke traditional cigarettes.

A number of short-term studies revealed that Vype can deliver nicotine efficiently to the consumer. We have also seen that switching completely from smoking to Vype can significantly reduce a person’s exposure to certain harmful chemicals.*

Effectively delivering nicotine could make Vype a viable alternative to a cigarette. Reducing exposure to harmful chemicals when smokers switch to Vype does not necessarily mean this product is less harmful than tobacco products, but may be an indicator of reduced risk potential.


*Harmful chemicals are defined by the following list: 1,3-butadiene, benzene, acetaldehyde, acrolein, B[a]P, CO, 2-aminonapthalene, acrylamide, acrylonitrile, ethylene oxide.

Population studies

Population studies help us understand how Vype might impact public health. Products like Vype are relatively new, and there is not a lot of information about their health effects. It took decades of use of cigarettes to fully appreciate their health effects. Rather than waiting decades, we are developing a computer modelling approach to assess whether making products like Vype available to smokers could have a beneficial effect on public health.

We used a mathematical model to investigate the impact of the availability of potentially reduced-risk products like vapour on public health.

Our results indicate that if vapour products, like Vype, were available and were seen to help reduce smoking prevalence, it would provide a stepping stone towards quitting smoking, and/or to increase smokers’ likelihood of quitting.

 

ePen 3

27

Behavioural science tests

Behavioural studies can help us understand how people use Vype products

82

Chemistry tests

Chemistry tests tell us what’s in Vype vapour

35

Biological tests

Biological tests tell us what the Vype vapour does to human cells in the lab

20

Clinical tests

Clinical studies help us understand the impact Vype has on people

95%*

Less toxicants

ePen 3 has 95%* less toxicants than cigarettes


*Comparison to 1R6F ref cigarette and vapour from Vype ePen 3, ref to 9 harmful components WHO recommends to reduce in cigarette smoke. This quality does not necessarily mean this product is less harmful than tobacco products
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