Dr Marianna Gaca and Dr James Murphy were both invited to present at the National Academy of Sciences in Washington DC last week, at a committee reviewing the health effects of Electronic Nicotine Delivery Systems (ENDS).
“We are proud to have represented the industry at this prestigious committee and played a key part in the discussions on ENDS. We feel this reflects BAT’s long standing commitment to openly and transparently sharing our science, as well as the high quality of our research” – says Chris Proctor, Chief Scientific Officer at BAT.
Dr Marianna Gaca shared results from our recent in vitro response studies comparing the effects of cigarettes smoke aerosol with e-cigarette vapour. She presented a wide spread of data, ranging from classical regulatory toxicology assays (including cytotoxicity), to disease models for lung cancer, COPD and CVD, systems biology and Adverse Outcome Pathways (AOPs). “We believe that in vitro holds great promise as a key part of a scientific assessment framework for e-cigarettes. We have demonstrated from our data that there are significant reductions in toxicity and biological activity in vitro when cells are exposed to e-cigarette aerosol versus tobacco smoke, although further scientific research will be required”, says Dr Gaca.
Dr James Murphy’s contribution focused on the role of clinical studies in assessing the risk reduction potential of next-generation nicotine products. “We recently published our assessment framework for substantiating the risk reduction potential of ENDS, and clinical studies are absolutely fundamental to these types of frameworks”, explains Dr Murphy.
Slides from both presentations are available to view through the bat-science library.
The National Academy of Sciences (NAS) is a US-based, private, non-profit organisation that “provides objective, science-based advice on critical issues”. They openly encourage research and education whilst recognising outstanding contributions to the field of science.
Videos of all presentations can be watched on demand via the event webpage .
Notes to Editors
About British American Tobacco: British American Tobacco is a global tobacco and Next Generation Product company with brands sold in more than 200 markets. It employs more than 50,000 people worldwide and has over 200 brands in its portfolio, with its cigarettes chosen by one in eight of the world’s one billion smokers. Leading global brands include Dunhill, Kent, Pall Mall and Lucky Strike.
About Next Generation Products (NGP): Next Generation Products is part of the British American Tobacco Group and is focused on developing and delivering high-quality alternative nicotine and tobacco products for adult consumers in the key areas of Vapour, Oral and Tobacco Heating Products. For more information see www.goVype.com and www.bat-science.com.
About Tobacco Harm Reduction: The only way to avoid the risks associated with tobacco use is not to consume tobacco at all, and the best way to reduce the risks is to stop using tobacco. However, the concept of harm reduction is increasingly being considered in relation to tobacco use. Harm reduction is about finding practical ways to minimise the health impact of an inherently risky activity or behaviour, without seeking to stop it entirely. It is a key element of BAT’s business strategy and is being discussed by some regulators. We think it’s important to work towards producing consumer-acceptable, potentially reduced risk products. We believe that tobacco regulatory policies should include harm reduction approaches for the millions of adults globally who will continue to consume tobacco products.
The Public Health Impact of e-cigarettes: Many in the public health community believe e-cigarettes offer great potential for contributing to tobacco harm reduction policies. A 2018 updated evidence review by Public Health England*, an executive body of the UK Department of Health, concludes that vaping is around 95% less harmful than smoking cigarettes. The UK’s Royal College of Physicians have said that the public can be reassured that e-cigarettes are much safer than smoking and that they should be widely promoted as a substitute for smoking.
For more information: email Joanna_Hunt@bat.com or call +44 (0)7858 375461